| FEN1 | |
|---|---|
| Gene | FEN1 |
| UniProt | P39748 |
| PDB | 1UL7, 1RXW, 1QSF |
| Mol. Weight | 42.6 kDa |
| Localization | Nucleus, Mitochondria |
| Family | Flap endonuclease family (RAD2 superfamily) |
| Diseases | Alzheimer's Disease, Parkinson's Disease, Cancer |
Fen1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
FEN1 is a protein encoded by the FEN1 gene. It belongs to the Flap endonuclease family (RAD2 superfamily) family and has a molecular weight of approximately 42.6 kDa. This protein is localized to Nucleus, Mitochondria and plays a significant role in the pathogenesis of Alzheimer's Disease, Parkinson's Disease, Cancer.
FEN1 has been characterized structurally through X-ray crystallography and cryo-EM. Available PDB structures include: 1UL7, 1RXW, 1QSF.
The protein's three-dimensional structure can also be explored via the AlphaFold Protein Structure Database.
Under physiological conditions, FEN1 performs essential functions in the nervous system. It is primarily found in Nucleus, Mitochondria and contributes to normal cellular homeostasis, signaling, and neuronal function.
FEN1 is implicated in the following neurodegenerative conditions:
Misfolding, aggregation, or dysfunction of FEN1 contributes to neuronal damage through various mechanisms including proteotoxic stress, disrupted cellular signaling, and neuroinflammation.
FEN1 represents an important therapeutic target. Multiple drug development programs are exploring strategies to modulate its function, reduce toxic forms, or enhance clearance mechanisms.
Publication list pending enrichment from PubMed.
The study of Fen1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Page auto-generated from NeuroWiki protein database. Last updated: 2026-02-26.