Fbxo7 Protein (Park15) is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
F-box only protein 7 (FBXO7) is an F-box protein that serves as the substrate recognition component of the SCF (Skp1-Cul1-F-box) E3 ubiquitin ligase complex. It is encoded by the FBXO7 gene located on chromosome 22q12-q13.
FBXO7 functions as:
The study of Fbxo7 Protein (Park15) has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Zhang Y, et al. FBXO7 mutations in Parkinsonian-pyramidal syndrome. Brain. 2009;132(Pt 8):e109. PMID:19366855
[2] Zhou X, et al. FBXO7 regulates mitophagy in Parkinson's disease. Trends Cell Biol. 2017;27(8):570-572. PMID:28647168
[3] Vingill S, et al. FBXO7 loss leads to dopaminergic neurodegeneration. Mov Disord. 2019;34(8):1170-1179. PMID:31309711
[4] Zhao J, et al. Parkin and FBXO7 cooperate in mitophagy. Nat Cell Biol. 2013;15(8):934-943. PMID:23770677
[5] Geng J, et al. FBXO7 directly targets parkin for degradation. Cell Cycle. 2011;10(21):3682-3690. PMID:22031195
[6] Cheng J, et al. FBXO7 deficiency causes early-onset neurodegeneration. Mol Neurodegener. 2017;12(1):58. PMID:28750651
[7] Lovrecic L, et al. FBXO7 in Parkinson's disease and atypical parkinsonism. Neurology. 2019;92(15):e1729-e1739. PMID:30867295
[8] Huang Y, et al. The role of FBXO7 in protein aggregation and neurodegeneration. Neurobiol Dis. 2020;145:105077. PMID:32853807