Elmo1 Protein Engulfment And Cell Motility 1 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
ELMO1 (Engulfment and Cell Motility 1) is a cytoplasmic protein that functions as a critical mediator of phagocytosis and cell migration. It works in conjunction with DOCK proteins to activate Rho GTPases, particularly Rac1, to orchestrate actin remodeling during engulfment processes [1]. [1]
ELMO1 is a modular protein with multiple functional regions: [2]
ELMO1 is essential for efficient phagocytosis: [3]
ELMO1 participates in several cellular processes: [4]
In microglia, ELMO1 is particularly important: [5]
ELMO1 has been implicated in PD through microglial function: [6]
ELMO1 represents a potential therapeutic target: [7]
The study of Elmo1 Protein Engulfment And Cell Motility 1 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Kang et al. ELMO1 in neuronal development and regeneration (Developmental Neurobiology, 2018). 2018. ↩︎
Zhang et al. ELMO1 in Parkinson's disease and alpha-synuclein clearance (Autophagy, 2020). 2020. ↩︎
Fitzgerald et al. ELMO1 in neuroinflammation and microglia activation (Journal of Neuroinflammation, 2019). 2019. ↩︎
Gao & Chen, ELMO1 in cell death and survival pathways (Cell Death & Disease, 2017). 2017. ↩︎
Hochreiter-Hufford & Ravichandran, ELMO1 and apoptotic cell clearance (Cold Spring Harbor Perspectives in Biology, 2013). 2013. ↩︎
Martinez & Ng, ELMO1 in immune signaling and neurodegeneration (Frontiers in Cellular Neuroscience, 2019). 2019. ↩︎
Brahma & Kumar, ELMO1 in cytoskeletal dynamics (Cellular and Molecular Life Sciences, 2016). 2016. ↩︎