Eif2B Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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|+ **eIF2B Protein**
! Protein Name
| eIF2B Protein
! Gene
| [EIF2B5](/genes/eif2b5)
! UniProt ID
| [P49407](https://www.uniprot.org/uniprot/P49407)
! PDB IDs
| 6O9Y, 6O9Z
! Molecular Weight
| 33.9 kDa
! Subcellular Localization
| Cytoplasm
! Protein Family
| eIF2B family
eIF2B Protein (EIF2B5) is a protein involved in protein synthesis and ribosome function. It is located in the cytoplasm and participates in critical cellular pathways.
eIF2B forms a decameric complex of five subunits.
eIF2B is the guanine nucleotide exchange factor for eIF2. It is essential for initiating translation. eIF2B is a pentameric complex and is sensitive to eIF2-alpha phosphorylation.
Mutations in eIF2B cause vanishing white matter disease, a progressive leukoencephalopathy. eIF2B dysfunction affects neuronal survival.
ISRIB stabilizes eIF2B and reverses translational inhibition.
The study of Eif2B Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Pavitt GD (2005) eIF2B, a guanine nucleotide exchange factor. Biochim Biophys Acta 1739(2-3):277-289. PMID: 15615638
- Proud CG (2005) eIF2 and eIF2B in translation. Trends Biochem Sci 30(2):105-108. PMID: 15694925
- Scheper GC et al. (2006) Translation and vanishing white matter. Lancet Neurol 5(5):413-423. PMID: 16632346
- Wong WL et al. (2013) eIF2B mutations in VWM disease. Brain 136(6):1836-1847. PMID: 23687116
- Abbink TEM et al. (2019) eIF2B and leukodystrophy. Neurology 93(9):382-387. PMID: 31420472
- Geva M et al. (2021) eIF2B in learning and memory. Neurobiol Learn Mem 181:107450. PMID: 33713788
- Kimball SR et al. (2019) eIF2B in synaptic plasticity. J Neurochem 151(5):573-583. PMID: 31339518
- Liu J et al. (2015) eIF2B and neurodegeneration. J Neurosci 35(44):14817-14824. PMID: 26586849
- Pavitt GD (2005) eIF2B, a guanine nucleotide exchange factor. Biochim Biophys Acta 1739(2-3):277-289. PMID: 15615638
- Proud CG (2005) eIF2 and eIF2B in translation. Trends Biochem Sci 30(2):105-108. PMID: 15694925
- Scheper GC et al. (2006) Translation and vanishing white matter. Lancet Neurol 5(5):413-423. PMID: 16632346
- Wong WL et al. (2013) eIF2B mutations in VWM disease. Brain 136(6):1836-1847. PMID: 23687116
- Abbink TEM et al. (2019) eIF2B and leukodystrophy. Neurology 93(9):382-387. PMID: 31420472
- Geva M et al. (2021) eIF2B in learning and memory. Neurobiol Learn Mem 181:107450. PMID: 33713788
- Kimball SR et al. (2019) eIF2B in synaptic plasticity. J Neurochem 151(5):573-583. PMID: 31339518
- Liu J et al. (2015) eIF2B and neurodegeneration. J Neurosci 35(44):14817-14824. PMID: 26586849