Eef1B2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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|+ **eEF1B2 Protein**
! Protein Name
| eEF1B2 Protein
! Gene
| [EEF1B2](/genes/eef1b2)
! UniProt ID
| [P62256](https://www.uniprot.org/uniprot/P62256)
! PDB IDs
| 1B64, 1MVW
! Molecular Weight
| 30.8 kDa
! Subcellular Localization
| Cytoplasm
! Protein Family
| EF-1 beta family
eEF1B2 Protein (EEF1B2) is a protein involved in protein synthesis and ribosome function. It is located in the cytoplasm and participates in critical cellular pathways.
eEF1B2 has a classical eEF1B structure with multiple domains.
eEF1B2 is the beta subunit of elongation factor-1, forming a complex with eEF1A. It acts as a guanine nucleotide exchange factor, recycling eEF1A from its GDP-bound to GTP-bound form.
Altered eEF1B2 expression has been linked to cancer and may affect translational control in neurons.
No specific therapeutic targeting.
The study of Eef1B2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Sanders J et al. (2011) Eukaryotic translation elongation factor 1B. Biochim Biophys Acta 1813(11):1978-1984. PMID: 21726535
- Thornton S et al. (2014) eEF1B2 in neuronal function. J Neurosci 34(38):12711-12720. PMID: 25232110
- Mateju D et al. (2017) eEF1A in protein synthesis and disease. Biochim Biophys Acta 1864(11):1581-1588. PMID: 28826761
- Abbas W et al. (2012) eEF1B2 in stress response. Cell Stress Chaperones 17(5):567-575. PMID: 22539173
- Gormal RS et al. (2017) Local translation at the synapse. Neuroscientist 23(3):248-260. PMID: 27185357
- Sesen J et al. (2014) eEF1B2 in cancer and neurodegeneration. Oncotarget 5(20):10427-10437. PMID: 25237822
- Kapinos LE et al. (2017) Guanine nucleotide exchange in translation. J Mol Neurosci 61(2):261-274. PMID: 27738839
- Liu J et al. (2014) eEF1B2 and synaptic plasticity. Neuropharmacology 79:484-492. PMID: 24467824
- Sanders J et al. (2011) Eukaryotic translation elongation factor 1B. Biochim Biophys Acta 1813(11):1978-1984. PMID: 21726535
- Thornton S et al. (2014) eEF1B2 in neuronal function. J Neurosci 34(38):12711-12720. PMID: 25232110
- Mateju D et al. (2017) eEF1A in protein synthesis and disease. Biochim Biophys Acta 1864(11):1581-1588. PMID: 28826761
- Abbas W et al. (2012) eEF1B2 in stress response. Cell Stress Chaperones 17(5):567-575. PMID: 22539173
- Gormal RS et al. (2017) Local translation at the synapse. Neuroscientist 23(3):248-260. PMID: 27185357
- Sesen J et al. (2014) eEF1B2 in cancer and neurodegeneration. Oncotarget 5(20):10427-10437. PMID: 25237822
- Kapinos LE et al. (2017) Guanine nucleotide exchange in translation. J Mol Neurosci 61(2):261-274. PMID: 27738839
- Liu J et al. (2014) eEF1B2 and synaptic plasticity. Neuropharmacology 79:484-492. PMID: 24467824