Dishevelled 2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
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| Protein Name |
Dishevelled 2 |
| Gene |
DVL2 |
| UniProt ID |
O14641 |
| PDB ID |
1L6O, 3L0O, 3C5G, 4WJI, 4WJJ, 4WJK |
| Molecular Weight |
79 kDa |
| Subcellular Localization |
Cytoplasm, Cell membrane, Synapses |
| Protein Family |
Dishevelled family |
Dishevelled 2 (DVL2) is a key scaffold protein in the Wnt signaling pathway, sharing functional redundancy with DVL1 and DVL3. It plays essential roles in embryonic development and neuronal function.
- Size: 713 amino acids
- Molecular weight: ~79 kDa
- Domains: DAX, PDZ, and DEP domains similar to DVL1
- Post-translational modifications: Phosphorylation, ubiquitination
- Wnt signaling: Central mediator of canonical and non-canonical Wnt pathways
- Synaptic function: Localizes to synapses, regulates synaptic protein trafficking
- Axon guidance: Mediates Wnt-directed axon guidance
- Neurogenesis: Regulates neural progenitor cell proliferation and differentiation
Alzheimer's Disease:
- Altered DVL2 expression in AD
- Interacts with APP processing
- Wnt signaling impairment contributes to pathology
Parkinson's Disease:
- DVL2 important for dopaminergic neuron survival
- Wnt signaling alterations in PD models
- Wallace et al. (2012). "Dvl2 and hearing/balance." Dev Biol. PMID: 22827944
- Chen et al. (2013). "Dishevelled proteins in synaptic plasticity." Neural Plast. PMID: 24348128
The study of Dishevelled 2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Dishevelled-2 in Wnt signal transduction (2019)
- DVL2 in embryonic brain development (2018)
- Dishevelled-2 planar cell polarity pathway (2020)
- DVL2 and dopaminergic neuron development (2019)
- Wnt/Dvl2 in synaptic function (2017)
- Dishevelled-2 in Parkinson's disease models (2021)
- DVL2-mediated signaling in neuronal survival (2020)
- Wnt pathway dysregulation in AD (2022)