{{ infobox-protein
| name = DUSP1 / MKP-1
| gene = DUSP1 [1]
| uniprot = P28562 [2]
| pdb = 1M3G, 1OZ0 [3]
| molecular_weight = 40 kDa
| localization = Nucleus, cytoplasm
| family = Dual-specificity MAP kinase phosphatases (DUSPs)
}}
DUSP1 (Dual Specificity Phosphatase 1), also known as MAPK Phosphatase-1 (MKP-1), is an inducible MAP kinase phosphatase that dephosphorylates both tyrosine and threonine residues on MAP kinases 1. It is a key negative regulator of stress-activated protein kinase signaling pathways.
DUSP1 is a 367 amino acid protein with:
The protein adopts a fold typical of PTP family phosphatases, with a conserved HCX5R motif in the active site 2.
| Interactor | Function |
|---|---|
| JNK1/2/3 | Dephosphorylation and inactivation |
| p38 α/β/γ | MAP kinase substrate |
| ERK1/2 | Dephosphorylation |
| p53 | Transcriptional regulation |
| c-Myc | Transcriptional co-activation |