| Doublecortin (DCX) | |
|---|---|
| Gene | DCX |
| UniProt | O43502 |
| PDB Structures | 1MJD, 2GJO |
| Molecular Weight | 40 kDa |
| Localization | Microtubules, neuronal soma and processes |
| Protein Family | Doublecortin family |
Doublecortin (Dcx) Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about this protein. See the content below for detailed information.
Doublecortin is a microtubule-associated protein essential for neuronal migration and cortical lamination. Mutations cause lissencephaly and double cortex syndrome, highlighting its critical role in brain development.
DCX has a distinctive architecture:
The doublecortin domain is a unique structural motif that distinguishes DCX from other MAPs.
In developing neurons, DCX performs critical functions:
DCX mutations cause X-linked lissencephaly:
The study of Doublecortin (Dcx) Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Gleeson JG, Lin PT, Flanagan KA, Walsh CA. "Doublecortin is a microtubule-associated protein expressed in migrating and differentiating neurons." Neuron. 1999;23(2):247-256. DOI:10.1016/S0896-6273(0080777-3
Francis F, Koulakoff A, Boucher D, Chafey P, Schaar B, et al. "Doublecortin is a developmentally regulated, microtubule-associated protein expressed in migrating and differentiating neurons." Neuron. 1999;23(2):257-271. DOI:10.1016/S0896-6273(0080778-5
Koizumi H, Higginbotham H, Pemble M, Endo S M, Goldman, et al. "Doublecortin maintains neuronal polarity in vivo and in vitro." Nat Commun. 2016;7:11043. DOI:10.1038/ncomms11043
Stott SR, Barker RA. "Doublecortin-expressing cells are associated with neurogenesis in the adult brain." Cell Tissue Res. 2015;361(1):27-38. DOI:10.1007/s00441-014-2063-x
Matsumoto N, Tanaka S, Ohshima Y, Yamada M, Hirohashi T, et al. "DCX and LIS1 in neuronal migration and development." Neurosci Res. 2019;147:28-37. DOI:10.1016/j.neures.2018.12.005