DAT1 is a protein that dat plays essential roles in:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
The dopamine transporter (DAT, also known as SLC6A3) is a membrane protein that reuptakes dopamine from the synaptic cleft back into presynaptic neurons, terminating dopamine signaling. It is a critical regulator of dopaminergic neurotransmission and a major target for psychostimulants and Parkinson's disease therapeutics.
DAT belongs to the neurotransmitter sodium symporter (NSS) family (SLC6). It consists of 12 transmembrane domains with intracellular N- and C-termini. The protein forms a central substrate-binding site that transports dopamine against a concentration gradient using Na+ and Cl- gradients.
| Property | Value |
|---|---|
| Gene | SLC6A3 |
| UniProt | Q01953 |
| Molecular Weight | ~79 kDa (705 amino acids) |
| Subcellular Localization | Plasma membrane, presynaptic terminals |
| Tissue Expression | Substantia nigra pars compacta, ventral tegmental area, striatum |
DAT plays essential roles in:
DAT function is directly affected in Parkinson's disease:
DAT is a primary target for:
| Drug/Compound | Mechanism | Clinical Use |
|---|---|---|
| Methylphenidate | DAT blocker | ADHD, narcolepsy |
| Amphetamine | DAT substrate/releaser | ADHD, narcolepsy |
| Modafinil | DAT inhibitor | Narcolepsy |
| Cocaine | DAT blocker | None (research) |