| CYP7B1 Protein — Oxysterol 7-alpha-hydroxylase | |
|---|---|
| Protein Name | Cytochrome P450 7B1 (Oxysterol 7-alpha-hydroxylase) |
| Gene | [CYP7B1](/genes/cyp7b1) |
| UniProt ID | O76074 |
| Molecular Weight | ~58 kDa (513 aa) |
| Subcellular Localization | Endoplasmic reticulum (membrane-bound) |
| Protein Family | Cytochrome P450 family |
| Expression | Liver, Brain, Kidney, Testis |
Cyp7B1 Protein Oxysterol 7 Alpha Hydroxylase is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
CYP7B1 Protein (Cytochrome P450 7B1) is a member of the cytochrome P450 enzyme family that catalyzes the 7-alpha hydroxylation of various sterols, playing a crucial role in cholesterol metabolism and bile acid synthesis [1]. This enzyme is essential for both the classic and alternative bile acid synthesis pathways.
CYP7B1 performs multiple hydroxylase reactions:
| Pathway | Substrate | Product | Significance |
|---|---|---|---|
| Classic bile acid synthesis | Cholesterol | 7-alpha-hydroxycholesterol | Primary bile acid synthesis |
| Alternative pathway | 27-Hydroxycholesterol | 7-alpha,27-dihydroxycholesterol | Important in humans |
| Oxysterol metabolism | 25-Hydroxycholesterol | 7-alpha,25-dihydroxycholesterol | Cholesterol homeostasis |
CYP7B1 mutations cause SPG5 through:
Loss of CYP7B1 function leads to:
The study of Cyp7B1 Protein Oxysterol 7 Alpha Hydroxylase has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.