| Complexin-1 Protein | |
|---|---|
| Protein Name | Complexin-1 (Synaphin-1) |
| Gene | CPLX1 |
| UniProt ID | O75178 |
| PDB ID | 1ZL9, 2N0P |
| Molecular Weight | 15 kDa |
| Subcellular Localization | Presynaptic terminals |
| Protein Family | Complexin family |
Complexin-1 (CPLX1) is a small cytosolic protein that regulates synaptic vesicle fusion by interacting with the SNARE complex. It serves as a key regulator of neurotransmitter release, functioning as both a fusion clamp that prevents premature fusion and a fusion activator that facilitates synchronized release. Complexin-1 is essential for fast synaptic transmission in the central nervous system, particularly in cerebellar and hippocampal synapses. Dysregulation of complexin-1 has been implicated in various neurological disorders, and its role in synaptic dysfunction makes it a protein of interest in neurodegenerative disease research.
Complexin-1 is a small soluble protein:
Complexin binds to assembled SNARE complexes and has both clamping and facilitating functions.
Complexin-1 regulates synaptic vesicle fusion: