| Complexin1 Protein — Synaphin 1 | |
|---|---|
| Gene | [CPLX1](/genes/cplx1) |
| UniProt | O95793 |
| Molecular Weight | 16 kDa |
| Subcellular Localization | Synaptic vesicles, presynaptic terminal |
| Protein Family | Complexin/Synaphin family |
| PDB Structures | 2B1K, 31XA |
Complexin1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Complexin1 (also known as Synaphin 1 or CPLX1) is a small synaptic protein that plays a critical role in regulating neurotransmitter release. It functions as a clamp that controls the timing of synaptic vesicle fusion during exocytosis. Complexin1 has been implicated in neurodegenerative diseases where synaptic dysfunction is a key feature.
Complexin1 is a 136-amino acid protein with:
Complexin1 regulates neurotransmitter release by:
In PD:
In AD:
In ALS:
The study of Complexin1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.