CHD5 (Chromodomain Helicase DNA-Binding Protein 5) is a neuron-specific ATP-dependent chromatin remodeler that functions as a potent transcriptional activator. CHD5 is expressed primarily in neuronal tissue where it regulates genes essential for neural development, synaptic plasticity, and cognitive function. As a tumor suppressor, CHD5 is frequently deleted in neuroblastoma and its dysfunction has been linked to neurodegenerative diseases. [1]
CHD5 protein is the neuron-specific member of the CHD family, distinguished by its restricted expression pattern and transcriptional activation function. Unlike other CHD proteins that primarily repress transcription, CHD5 activates neuronal gene expression programs through chromatin remodeling and recruitment of histone modifiers. CHD5 is essential for memory formation and its dysfunction contributes to cognitive decline in aging and disease. [2]
| Property | Value |
|---|---|
| Protein Name | CHD5 |
| Gene | CHD5 |
| UniProt ID | Q8TDC0 |
| PDB ID | 5MLM |
| Molecular Weight | 260 kDa |
| Subcellular Localization | Nucleus (chromatin-associated) |
| Protein Family | CHD family, SNF2 superfamily |
| Aliases | CHD5, NEDE, KIAA1731 |
CHD5 protein contains characteristic CHD family domains:
CHD5 in neurons:
CHD5 contributes to AD:
CHD5 is a major tumor suppressor:
CHD5 haploinsufficiency causes:
Hu et al. BRG1 in neurodegeneration, J Neurosci (2020). 2020. ↩︎
D'Alessio et al. CBX7 in aging and cancer, Aging Cell (2018). 2018. ↩︎