Cav2.3 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Cav2.3 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Cav2.3 is the α1E subunit of voltage-gated calcium channels, forming the pore of the R-type calcium channel. It is encoded by the CACNA1E gene.
| Property | Value |
|---|---|
| Protein Name | Cav2.3 (Voltage-dependent R-type calcium channel subunit α1E) |
| Gene | CACNA1E |
| UniProt ID | Q15878 |
| PDB Structure | 6JPA, 6JPL |
| Molecular Weight | ~250 kDa (α1 subunit) |
| Subcellular Localization | Dendritic shafts and spines, cell body |
| Protein Family | Voltage-gated calcium channel α1 family (CaV2) |
Cav2.3 contains the typical structure of voltage-gated calcium channel α1 subunits:
Key structural features:
In neurons, Cav2.3 (R-type) channels contribute to:
| Approach | Compound | Status | Notes |
|---|---|---|---|
| Direct blocker | SNX-482 | Research | Peptide toxin from tarantula, selective for Cav2.3 |
| Small molecule | Y5AA-311N | Preclinical | Synthetic R-type channel blocker |
| Indirect modulation | Ethosuximide | Approved | Used for absence seizures, off-target effects |
| Gene therapy | ASO | Preclinical | Antisense oligonucleotides to reduce expression |
Cav2.3 dysfunction may be assessed through:
Cav2.3 Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Cav2.3 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
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