Cathepsin L Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Cathepsin L is a lysosomal cysteine protease encoded by the CTSL gene. It belongs to the papain family (family C1) of cysteine proteases and plays essential roles in intracellular protein degradation, antigen processing, and various physiological and pathological processes. Cathepsin L is one of the most active lysosomal proteases and is crucial for normal cellular function. [1]
| Property | Value | [2]
|----------|-------| [3]
| Protein Name | Cathepsin L | [4]
| Gene | CTSL |
| UniProt ID | P07711 |
| PDB ID | 2YJC |
| Molecular Weight | 33 kDa (proenzyme), 25 kDa (mature enzyme) |
| Subcellular Localization | Lysosome |
| Protein Family | Papain family (C1A) |
Cathepsin L is synthesized as a preproenzyme:
The mature enzyme contains:
Cathepsin L degrades proteins in lysosomes as part of normal cellular protein turnover:
Cathepsin L has complex roles in AD:
Cathepsin L activity can be measured in:
[5:1] Cataldo AM, et al. (1990). Properties of the amyloid β-protein precursor degrading enzyme(s) in brain. Journal of Neurochemistry.
[1:2] McGowan E, et al. (2005). Alpha-synuclein and neurodegeneration. Neurochemical Research.
The study of Cathepsin L Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Walkley SU, et al. "Lysosomal storage diseases: Pathways and therapeutic strategies." Nat Rev Neurol. Nat Rev Neurol. 2023. ↩︎ ↩︎ ↩︎
Parenti G, et al. "Lysosomal storage diseases: From pathophysiology to therapy." Adv Pharmacol. Adv Pharmacol. 2023. ↩︎
Sun A. "Lysosomal storage disease overview." J Biochem. J Biochem. 2022. ↩︎
Wang RY, et al. "Enzyme replacement therapy for mucopolysaccharidoses." Mol Genet Metab. Mol Genet Metab. 2021. ↩︎
Platt FM, et al. "Lysosomal storage disorders." Nat Rev Dis Primers. Nat Rev Dis Primers. 2024. ↩︎ ↩︎