Cathepsin E is an aspartic protease predominantly expressed in immune cells and the gastrointestinal tract. Unlike cathepsins B, D, and E, it is not a typical lysosomal protease but localizes to endosomes. It may play roles in antigen processing and amyloid-beta degradation in AD.
Cathepsin E Protein is encoded by the CTSE gene. It is a Aspartic protease, endosomal/lysosomal with a molecular weight of approximately 437 aa. The protein localizes to Endoplasmic reticulum, Lysosomes, Cytoplasm. [1]
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The Cathepsin E Protein contains characteristic domains for its function as a Aspartic protease, endosomal/lysosomal. Structural information is available from UniProt and the PDB. [3]
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Cathepsin E is an aspartic protease predominantly expressed in immune cells and the gastrointestinal tract. Unlike cathepsins B, D, and E, it is not a typical lysosomal protease but localizes to endosomes. It may play roles in antigen processing and amyloid-beta degradation in AD. [5]
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Dysfunction of Cathepsin E Protein has been implicated in several neurodegenerative diseases: [7]
Research into therapeutic modulation of Cathepsin E Protein includes:
Hook VY, Toneff T, Aaron W, et al. Cathepsin B and cathepsin D expression in the hippocampal formation and olfactory bulb in Alzheimer's disease. 2002. ↩︎
Bernstein HG, Kirschke H, Wiederanders B, et al. The possible role of cathepsin D in Alzheimer's disease. 1994. ↩︎
Mueller-Steiner S, Zhou Y, Arai H, et al. Antiamyloidogenic and neuroprotective functions of cathepsin B: implications for Alzheimer's disease. 2006. ↩︎
Zhang J, Kang DE, Xia W, et al. Cathepsin D: structure, function, and role in Alzheimer disease. 2005. ↩︎
Nakanishi H. Cathepsin E and cathepsin D in the brain. 2005. ↩︎
Bae EJ, Lee SJ, Kim YH, et al. Cathepsin D and beta-amyloid metabolism: implications in Alzheimer's disease. 2008. ↩︎
Conus S, Simon HU. Cathepsins and their role in cancer progression. 2009. ↩︎