Cathepsin E is an aspartic protease predominantly expressed in immune cells and the gastrointestinal tract. Unlike cathepsins B, D, and E, it is not a typical lysosomal protease but localizes to endosomes. It may play roles in antigen processing and amyloid-beta degradation in AD.
Cathepsin E Protein is encoded by the CTSE gene. It is a Aspartic protease, endosomal/lysosomal with a molecular weight of approximately 437 aa. The protein localizes to Endoplasmic reticulum, Lysosomes, Cytoplasm.
The Cathepsin E Protein contains characteristic domains for its function as a Aspartic protease, endosomal/lysosomal. Structural information is available from UniProt and the PDB.
Cathepsin E is an aspartic protease predominantly expressed in immune cells and the gastrointestinal tract. Unlike cathepsins B, D, and E, it is not a typical lysosomal protease but localizes to endosomes. It may play roles in antigen processing and amyloid-beta degradation in AD.
Dysfunction of Cathepsin E Protein has been implicated in several neurodegenerative diseases:
Research into therapeutic modulation of Cathepsin E Protein includes: