| CASR — Calcium-Sensing Receptor Protein | |
|---|---|
| Protein Name | Calcium-Sensing Receptor Protein |
| Gene | CASR |
| UniProt ID | Q9UII2 |
| PDB IDs | 5K5J |
| Molecular Weight | 120 kDa |
| Subcellular Localization | Plasma membrane |
| Protein Family | C family (Class C GPCR) |
The Calcium-Sensing Receptor (CaSR) is a G protein-coupled receptor that detects extracellular calcium levels. In the brain, CaSR is involved in synaptic plasticity, neuronal excitability, and has been implicated in neurodegenerative processes. CaSR modulators may have therapeutic potential in AD and PD.
The CASR protein contains specific domains that mediate its function within neuronal cells. Structural studies have provided insights into the molecular mechanisms of CASR action.
CASR undergoes various post-translational modifications that regulate its activity, localization, and protein interactions.
CASR plays important roles in normal neuronal function:
CASR has been implicated in Alzheimer's disease pathogenesis through various mechanisms including amyloid processing, tau pathology, synaptic dysfunction, or neuronal loss.
CASR may contribute to dopaminergic neuron survival, protein aggregation, or mitochondrial dysfunction in Parkinson's disease.
CASR may also play roles in ALS, Huntington's disease, and other neurodegenerative conditions.
Understanding CASR function in neurodegeneration may lead to therapeutic strategies targeting: