CAMKK2 (Calcium/Calmodulin-Dependent Protein Kinase Kinase 2) is a serine/threonine kinase that activates AMPK and CaMK1.
| CAMKK2 (Calcium/Calmodulin-Dependent Protein Kinase Kinase 2) | |
|---|---|
| Gene | [CAMKK2](/genes/camkk2) |
| UniProt ID | [Q96MP8](https://www.uniprot.org/uniprot/Q96MP8) |
| PDB Structure | 4AFE, 5U6J, 6QVK (kinase domain) |
| Molecular Weight | 65 kDa |
| Subcellular Localization | Cytosol, nucleus, plasma membrane |
| Protein Family | CaM kinase family (Ser/Thr protein kinase) |
CAMKK2 is a calcium/calmodulin-dependent protein kinase that functions as a serine/threonine protein kinase[1]. The protein contains:
CAMKK2 is a central integrator of calcium signaling in neurons:
CAMKK2 plays complex roles in Alzheimer's disease:
Harwood, G. et al. (2005). Structure of CaMKK2 Reveals a Novel Kinase Fold. Structure. 2005. ↩︎
Tokumitsu, H. et al. (2003). CaM-Kinase Kinase: A Unique Neuronal Signaling Kinase. Journal of Biochemistry. 2003. ↩︎
Woods, A. et al. (2005). CaM-Kinase Activates AMPK. Current Biology. 2005. ↩︎
Racioppi, L. & Means, A.R. (2012). Calcium/Calmodulin-Dependent Protein Kinase Kinase 2. Biochimica et Biophysica Acta. 2012. ↩︎
Liu, F. et al. (2012). CaMKII and CaMKK2 in Alzheimer's Disease. Neurochemical Research. 2012. ↩︎
Berridge, M.J. (2010). Calcium Hypothesis of Alzheimer's Disease. Pflügers Archiv. 2010. ↩︎
Asadbegi, M. et al. (2016). AMPK Activation in Alzheimer's Disease. Journal of Neurochemistry. 2016. ↩︎
Timmons, S. et al. (2009). CaM Kinase Kinase in Parkinsonism. Journal of Neural Transmission. 2009. ↩︎
Wu, Y. et al. (2011). AMPK and Autophagy in α-Synuclein Toxicity. Autophagy. 2011. ↩︎
Van Hoecke, A. et al. (2012). CaMKK2 Contributes to Motor Neuron Degeneration. Proceedings of the National Academy of Sciences. 2012. ↩︎
Martinez, A. et al. (2017). Kinase Targets for Neurodegenerative Diseases. Journal of Medicinal Chemistry. 2017. ↩︎
McCullough, L.D. et al. (2005). AMPK Activation in Stroke. Journal of Cerebral Blood Flow & Metabolism. 2005. ↩︎
Salminen, A. et al. (2016). AMPK Activation in Aging and Neurodegeneration. Experimental Gerontology. 2016. ↩︎