Calmodulin 2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
Calmodulin-2
| Protein Name | Calmodulin-2 |
| Gene Symbol | CALM2 |
| UniProt ID | P62158 |
| PDB ID | 1CLL, 1CTR |
| Molecular Weight | 16.7 kDa |
| Subcellular Localization | Cytoplasm, Nucleus |
| Protein Family | Calmodulin (EF-hand calcium-binding protein) |
| Associated Diseases | Alzheimer's Disease, Parkinson's Disease, Cardiac Arrhythmias, Epilepsy |
Calmodulin-2 (CALM2 encoded) is a Calmodulin (EF-hand calcium-binding protein) that plays critical roles in Calcium sensor regulating over 100 target proteins. This protein is implicated in the pathogenesis of several neurodegenerative diseases through its involvement in calcium signaling, neuronal excitability, cardiac function.
Calmodulin-2 has an identical amino acid sequence to calmodulin-1 (encoded by different genes). The protein contains four EF-hand calcium-binding domains arranged in a dumbbell shape.
Calmodulin-2 is functionally identical to calmodulin-1 but is differentially expressed in tissues. It serves as a calcium sensor for numerous target proteins and is essential for calcium-dependent signaling in all cell types.
Calmodulin-2 is involved in calcium dysregulation in neurodegenerative diseases similar to calmodulin-1.
| Disease | Pathogenic Mechanism |
|---|---|
| Alzheimer's Disease | Pathogenic variants |
| Parkinson's Disease | Pathogenic variants |
| Cardiac Arrhythmias | Pathogenic variants |
| Epilepsy | Pathogenic variants |
Cardiac-specific functions make CALM2 relevant for understanding cardiac complications in neurodegenerative diseases.
Therapeutic strategies targeting calmodulin-2 face the same challenges as for calmodulin-1.
The study of Calmodulin 2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.