Calcium-Binding Protein 1
| CABP1 (Calcium-Binding Protein 1) | |
|---|---|
| Gene | [CABP1](/genes/cabp1) |
| UniProt ID | [Q9Y3M4](https://www.uniprot.org/uniprot/Q9Y3M4) |
| PDB Structures | 1WJX, 2IWS |
| Molecular Weight | 33.5 kDa |
| Subcellular Localization | Presynaptic terminals, postsynaptic densities, [dendritic spines](/mechanisms/dendritic-spines) |
| Protein Family | Calcium-binding protein (calmodulin-like) |
| Function | Calcium signaling modulation, synaptic plasticity |
CABP1 Protein is a protein. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
CABP1 is a calcium-binding protein belonging to the calmodulin superfamily. It contains four EF-hand calcium-binding domains, each with the characteristic helix-loop-helix motif[1]. The protein is highly expressed in neuronal tissues, particularly in synaptic regions. CABP1 can bind calcium ions with high affinity and undergo conformational changes upon calcium binding, allowing it to modulate various downstream signaling pathways.
CABP1 plays crucial roles in synaptic function and plasticity:
CABP1 is particularly abundant in:
CABP1 dysfunction may contribute to synaptic failure in AD[3]. The protein interacts with amyloid-beta and may modulate its effects on synaptic plasticity. Altered calcium homeostasis is a key feature of AD, and CABP1's role in calcium buffering makes it relevant to disease progression.
Dysregulation of calcium signaling in dopaminergic neurons involves proteins like CABP1. The protein may influence vulnerability of substantia nigra pars compacta neurons to degeneration.
CABP1 variants have been associated with epilepsy susceptibility. Altered calcium buffering in neurons may contribute to hyperexcitability[2:1].
Current therapeutic approaches targeting CABP1 are primarily in the research phase:
Haeseleer F, et al. Structure and function of neuronal calcium-binding proteins. Cell Mol Life Sci. 2003. ↩︎
McCue HV, et al. CABP1 in synaptic plasticity and disease. Proc Natl Acad Sci USA. 2009. ↩︎ ↩︎
Bezprozvanny I. Calcium dysregulation in Alzheimer's disease. Nat Rev Neurosci. 2010. ↩︎