C5 Protein is a protein encoded by the C5 gene that c5 functions in the complement cascade:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target. [1]
Complement Component 5 (C5) is a critical protein in the complement system, a key component of innate immunity. C5 is cleaved into C5a (anaphylatoxin) and C5b, which initiate inflammation and membrane attack complex formation. The complement system is heavily implicated in neuroinflammation and neurodegenerative diseases. [2]
C5 is a large plasma protein: [3]
| Property | Value | [4]
|----------|-------|
| Gene | C5 |
| UniProt | P01031 |
| Molecular Weight | ~190 kDa |
| Subcellular Localization | Plasma |
| Protein Family | Complement system |
C5 functions in the complement cascade:
| Agent | Mechanism | Status |
|---|---|---|
| Avacopan | C5aR1 antagonist | Approved (vasculitis) |
| Eculizumab | C5 inhibitor | Approved (PNH/aHUS) |
| RA101295 | C5 inhibitor | Clinical trials |
Zhou et al. C5a in Alzheimer's disease (2022). 2022. ↩︎
Hawkins et al. Complement in Parkinson's disease (2021). 2021. ↩︎
Brenner et al. Complement in ALS (2021). 2021. ↩︎
Michaud et al. C5aR1 in neurodegeneration (2022). 2022. ↩︎