Bone Morphogenetic Protein 2 (BMP2) is a member of the TGF-β superfamily with critical roles in embryonic development, bone formation, and neural development. It has complex roles in neurodegeneration and neural repair.
BMP2 (Bone Morphogenetic Protein 2) is a member of the TGF-beta superfamily that functions as a growth factor. BMP2 signals through BMP receptors to regulate cell proliferation, differentiation, and apoptosis. In the nervous system, BMP2 plays important roles in neural patterning, neurogenesis, and synaptic plasticity. BMP2 signaling is implicated in neurodegenerative processes and brain repair. [1]
BMP2 is a secreted growth factor: [2]
BMP2 signals through type I and type II receptor complexes. [3]
BMP2 has diverse biological functions:
Signaling involves BMP type I receptors (BMPR1A/ALK3, BMPR1B/ALK6) and type II receptors (BMPR2), activating SMAD1/5/8.
BMP2 modulation:
Chen et al. BMP signaling in neurogenesis and neurodegenerative diseases (2008). 2008. ↩︎
Liu et al. BMP2 protects dopaminergic neurons against neurotoxicity (2009). 2009. ↩︎
Shaltouki et al. BMP2 as a therapeutic agent for Parkinson's disease (2014). 2014. ↩︎