Protein Name: AXL (AXL Receptor Tyrosine Kinase)
Gene: AXL
UniProt ID: Q9U6C5
Molecular Weight: 140 kDa (full-length)
Subcellular Localization: Cell membrane, Endosomes
Protein Family: TAM Receptor Tyrosine Kinase Family
AXL is a type I transmembrane receptor with the following architecture:
The receptor exists as both monomer and dimer on the cell surface, with dimerization required for activation[1].
AXL signaling promotes cell survival through:
AXL plays important roles in innate immunity:
AXL is involved in:
AXL is upregulated in AD and contributes to:
Therapeutic modulation of AXL could reduce neuroinflammation and enhance amyloid clearance[2].
In PD, AXL may play protective roles:
AXL is implicated in ALS pathogenesis:
Multiple AXL inhibitors are in clinical development:
For neurodegeneration, AXL inhibitors may reduce harmful microglial activation.
AXL activators (Gas6 mimetics) could potentially:
Linger RM, et al. (2010). "TAM receptor tyrosine kinases as therapeutic targets in cancer." Pharmacol Ther. 128(3):374-385. DOI: 10.1016/j.pharmthera.2010.08.001[1:1]
Kim J, et al. (2019). "AXL regulates microglial activation and contributes to Alzheimer's disease pathogenesis." Mol Neurodegener. 14(1):31. DOI: 10.1186/s13024-019-0329-1[2:1]
Linger RM, et al. (2010). "TAM receptor tyrosine kinases as therapeutic targets in cancer." Pharmacol Ther. 128(3):374-385. DOI: 10.1016/j.pharmthera.2010.08.001 ↩︎ ↩︎
Kim J, et al. (2019). "AXL regulates microglial activation and contributes to Alzheimer's disease pathogenesis." Mol Neurodegener. 14(1):31. DOI: 10.1186/s13024-019-0329-1 ↩︎ ↩︎