ATP6AP2 is a protein encoded by the ATP6AP2 gene that atp6ap2 plays essential roles in:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
Associated Diseases: [Parkinson's Disease](/diseases/parkinsons-disease-disease), [Huntington's Disease](/diseases/huntington-disease), [Schizophrenia](/diseases/schizophrenia)
ATP6AP2 (ATPase H+ Transporting Accessory Protein 2), also known as the (Pro)renin receptor, is a single-pass transmembrane protein (350 amino acids) with a large extracellular domain, a single transmembrane helix, and a short cytoplasmic tail. The extracellular domain contains a Cys-rich domain that binds renin and prorenin, enabling their catalytic activity independent of angiotensin conversion.
ATP6AP2 plays essential roles in:
Dysregulation of ATP6AP2 is implicated in several neurodegenerative disorders:
ATP6AP2 remains an emerging therapeutic target: