Atp5B Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| ATP5B — ATP Synthase Subunit Beta | |
|---|---|
| Protein Name | ATP Synthase Subunit Beta |
| Gene | [ATP5B](/genes/atp5b) |
| UniProt ID | [P06576](https://www.uniprot.org/uniprot/P06576) |
| PDB ID | 1BM1, 2JDI |
| Molecular Weight | ~56 kDa |
| Subcellular Localization | Mitochondrial inner membrane (F1 sector) |
| Protein Family | ATP synthase alpha/beta chain family |
ATP5B (ATP Synthase Subunit Beta) is the catalytic beta subunit of mitochondrial ATP synthase (Complex V). This is the primary catalytic subunit responsible for the synthesis of ATP from ADP and inorganic phosphate using the proton gradient.
The F1 domain contains three alpha and three beta subunits arranged in a hexameric ring. The beta subunits are the main catalytic components.
ATP5B features:
The study of Atp5B Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.