Atp5A1 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| ATP5A1 — ATP Synthase Subunit Alpha | |
|---|---|
| Protein Name | ATP Synthase Subunit Alpha |
| Gene | ATP5A1 |
| UniProt ID | P25788 |
| PDB ID | 6CP6, 6GMH |
| Molecular Weight | ~60 kDa |
| Subcellular Localization | Mitochondrial inner membrane (F1 sector) |
| Protein Family | ATP synthase alpha/beta chain family |
ATP5A1 (ATP Synthase Subunit Alpha) is the catalytic alpha subunit of mitochondrial ATP synthase (Complex V). This enzyme is responsible for the final step of oxidative phosphorylation - converting the proton gradient into chemical energy in the form of ATP.
ATP synthase is a large multisubunit complex (~600 kDa) consisting of:
The alpha subunit is part of the F1 catalytic domain which contains the nucleotide binding sites.
ATP5A1 structure:
The study of Atp5A1 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.