| ATPase Phospholipid Transporting 10B (ATP10B) | |
|---|---|
| Gene | [ATP10B](/genes/atp10b) |
| UniProt ID | [Q9CQ40](https://www.uniprot.org/uniprotkb/Q9CQ40/entry) |
| PDB Structure | No structure available |
| Molecular Weight | 128.5 kDa |
| Subcellular Localization | Endoplasmic reticulum, Lysosomes |
| Protein Family | P4-ATPase (ATPase class IV) family |
ATP10B Protein is a protein. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
ATP10B is a member of the P4-ATPase family (ATPase class IV) that catalyzes phospholipid translocation across cellular membranes[1]. These enzymes use ATP to flip phospholipids from the outer to inner leaflet, creating membrane asymmetry crucial for vesicle trafficking and signaling[2]. ATP10B contains 10 transmembrane helices and characteristic P4-ATPase motifs including the phosphorylation domain (DKTGTLT)[3].
ATP10B is expressed in various tissues including brain, with particular abundance in neurons and glial cells[4]. The protein localizes to the endoplasmic reticulum and lysosomal membranes, where it participates in phospholipid metabolism and membrane trafficking[5]. ATP10B is essential for maintaining cellular lipid homeostasis and proper vesicular transport between intracellular compartments[6].
ATP10B has emerged as a significant genetic risk factor for Parkinson's disease. Rare loss-of-function mutations in ATP10B have been associated with increased PD risk[7]. The protein plays a protective role against mitochondrial dysfunction and oxidative stress, which are central to PD pathogenesis[8]. ATP10B deficiency leads to increased susceptibility to mitochondrial toxins and impaired lysosomal function[9].
Studies have identified ATP10B variants in Lewy body dementia patients, suggesting a role in this neurodegenerative condition characterized by alpha-synuclein aggregation[10].
ATP10B dysfunction may contribute to tau pathology through impaired membrane trafficking and altered lipid raft composition[11].
P4-ATPase family. Biochimica et Biophysica Acta. ↩︎
Phospholipid flippases. Trends in Cell Biology. 2019. ↩︎
ATP10B structure. UniProt. ↩︎
ATP10B expression in brain. Journal of Comparative Neurology. ↩︎
ATP10B subcellular localization. Journal of Neuropathology & Experimental Neurology. ↩︎
P4-ATPases in membrane trafficking. Traffic. ↩︎
Apex et al. ATP10B and PD. Brain. 2020. ↩︎
Chen et al. ATP10B and mitochondria. Nature Communications. 2021. ↩︎
ATP10B and lysosomal function. Neurobiology of Aging. 2022. ↩︎
ATP10B in LBD. Neurology. ↩︎
ATP10B and tau pathology. Acta Neuropathologica. ↩︎
ATP10B therapeutic strategies. Nature Reviews Neurology. ↩︎