{{> infobox .infobox-protein
| name = ATOX1 Protein
| gene = ATOX1
| uniprot = O00244
| pdb = 1TL4
| molecular_weight = ~9 kDa
| localization = Cytosol, Nucleus
| family = Copper chaperone family
}}
{{> infobox is a protein. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
ATOX1 (Antioxidant 1 Copper Chaperone) is a small soluble protein (~68 amino acids) with a conserved MXHCXXC motif that coordinates copper ions. The protein adopts a ferredoxin-like fold with a central β-sheet flanked by α-helices. ATOX1 forms homodimers in solution and contains a conserved C-terminal tail involved in nuclear localization.
ATOX1 functions as a copper delivery chaperone in neurons:
[1] ATOX1 is implicated in AD pathogenesis:
[2] In PD, ATOX1 alterations affect:
[3] While primarily a liver disease, ATOX1 mutations cause: