ASTN1 Protein
ASTN1 (Astrotactin 1) is a neuronal membrane protein that functions as a receptor for neuronal migration during development and synaptic plasticity in the mature nervous system. The ASTN1 protein mediates homophilic and heterophilic interactions with other adhesion molecules at the neuronal surface. During brain development, ASTN1 enables glial-guided migration of neurons through the developing cortex and cerebellum. In adult brains, ASTN1 continues to be expressed at synapses where it may contribute to synaptic stability and plasticity. ASTN1 variants have been implicated in neurodevelopmental disorders, and understanding its function may provide insights into synaptic mechanisms relevant to neurodegeneration.
Astrotactin-1 is a neuronal adhesion protein that functions as a receptor for glial-guided neuronal migration during brain development. It contains multiple fibronectin type III domains and interacts with the actin cytoskeleton.
Astrotactin-1 is a neuronal adhesion protein that functions as a receptor for glial-guided neuronal migration during brain development. It contains multiple fibronectin type III domains and interacts with the actin cytoskeleton.
ASTN1 variants affect neuronal migration and cortical development, leading to neurodevelopmental disorders.
Gene therapy approaches to restore ASTN1 function are being explored.