Apoer2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
ApoER2 (Apolipoprotein E Receptor 2), also known as LRP8, is a member of the Low-Density Lipoprotein Receptor family. It is primarily expressed in the brain and plays critical roles in synaptic function, neuronal development, and lipid metabolism. ApoER2 is a key receptor for both Reelin signaling and apolipoprotein E (APOE)-containing lipoproteins, making it a crucial nexus between lipid metabolism and neuronal function. The receptor is expressed predominantly in neurons throughout the brain, with highest levels in the hippocampus, cortex, and cerebellum. [1]
| Attribute | Value | [2]
|-----------|-------| [3]
| Gene Symbol | LRP8 | [4]
| Protein Name | Apolipoprotein E Receptor 2 (ApoER2) | [5]
| Molecular Weight | ~110 kDa (full-length), 85 kDa (truncated) | [6]
| Structure | 963 amino acids | [7]
| Aliases | LDLRR, LR8, APOER2 |
| UniProt ID | Q9UBJ2 |
| Tissue Expression | Brain (neurons), testis, platelets |
ApoER2 is a type I transmembrane glycoprotein with multiple functional domains:
ApoER2 is the primary Reelin receptor in neurons:
| Partner | Interaction Type | Functional Consequence |
|---|---|---|
| Reelin | Ligand binding | Neuronal migration, plasticity |
| VLDLR | Co-receptor | Signal amplification |
| Dab1 | Adaptor protein | Signal transduction |
| APOE | Ligand binding | Lipid transport |
| NMDA Receptor | Physical association | Synaptic modulation |
| PSD-95 | Scaffold interaction | Synaptic localization |
| Approach | Status | Mechanism |
|---|---|---|
| Reelin mimetics | Preclinical | Activate ApoER2 signaling |
| Dab1 stabilizers | Discovery | Enhance downstream signaling |
| Small molecule modulators | Preclinical | Modulate receptor activity |
The study of Apoer2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Herz and Chen, 2006. LRP8 in neurodegeneration. Nat Rev Neurosci. 2006. ↩︎
Lane-Donovan et al., 2014. Lipoprotein receptors in brain function. 2014. ↩︎
Beffert et al., 2005. ApoER2 and Reelin in synaptic plasticity. 2005. ↩︎
D'Arcangelo et al., 2009. Reelin signaling in neuropsychiatric disease. 2009. ↩︎
Chen et al., 2010. LRP8 and Alzheimer's disease. 2010. ↩︎
Hiesberger et al., 1999. Direct binding of Reelin to ApoER2. 1999. ↩︎
Bal et al., 2013. ApoER2 and NMDA receptor function. 2013. ↩︎