Anxa2 Protein — Annexin A2 is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
ANXA2 (Annexin A2) is a calcium-dependent phospholipid-binding protein that participates in various cellular processes including membrane organization, endocytosis, and signal transduction. ANXA2 exists as both a monomer and heterotetramer with S100A10, and has been implicated in neurodegeneration and cancer[1].
The ANXA2 protein contains:
| Domain | Residues | Function |
|---|---|---|
| N-terminus | 1-30 | S100A10 binding |
| Repeat I | 31-100 | Calcium binding |
| Repeat II | 101-170 | Calcium binding |
| Repeat III | 171-240 | Calcium binding |
| Repeat IV | 241-338 | Calcium binding |
ANXA2 functions as[2]:
The ANXA2-S100A10 heterotetramer:
ANXA2 participates in:
ANXA2 in signal transduction:
In AD[3]:
In PD:
In oncology[4]:
| Tissue | Expression | Notes |
|---|---|---|
| Endothelium | High | Vascular function |
| Epithelium | Moderate | Tissue-specific |
| Neurons | Moderate | Brain function |
| Immune cells | Variable | Activation-dependent |
| Strategy | Approach | Status | Notes |
|---|---|---|---|
| ANXA2 Inhibitors | Cancer therapy | Research | Cytotoxicity |
| Antibodies | Diagnostic | Research | Biomarker |
| Peptides | Therapy | Research | Disrupt function |
Anxa2 knockout mice show:
The study of Anxa2 Protein — Annexin A2 has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Gerke V, et al. Annexins: Structure and function. Cell Mol Life Sci. 2022. ↩︎
Moss SE, et al. Annexin A2 in cell biology. J Cell Sci. 2021. ↩︎
Liu Y, et al. Annexin A2 in Alzheimer's disease. J Alzheimers Dis. 2022. ↩︎
Zhao S, et al. Annexin A2 in cancer. Cancer Lett. 2023. ↩︎