ANT2 Protein is a protein encoded by the SLC25A5 gene that ant2 has distinct physiological roles:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
ANT2 (Adenine Nucleotide Translocase 2), encoded by SLC25A5, is a mitochondrial carrier protein that exchanges ADP and ATP across the inner mitochondrial membrane, with highest expression in proliferating cells.
| Property | Value |
|---|---|
| Gene | SLC25A5 |
| UniProt | P05141 |
| PDB | 6G2D, 6G2F |
| Molecular Weight | ~33 kDa |
| Subcellular Localization | Mitochondrial inner membrane |
| Protein Family | Mitochondrial carrier (SLC25) family |
ANT2 has the classic mitochondrial carrier fold with six transmembrane helices forming three tandem repeats. It contains the signature carrier motifs and forms homodimers for function. The protein has different regulatory properties compared to ANT1 and ANT3.
ANT2 has distinct physiological roles: