Annexin A11 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
This page provides comprehensive information about Annexin A11 Protein, including its structure, normal function in the nervous system, and its role in neurodegenerative diseases. [1]
| Annexin A11 | |
|---|---|
| Protein Name | Annexin A11 |
| Gene | [ANXA11](/genes/anxa11) |
| UniProt ID | [P50991](https://www.uniprot.org/uniprot/P50991) |
| PDB ID | 5YUE, 6B8J |
| Molecular Weight | 54 kDa |
| Subcellular Localization | Cytoplasm, plasma membrane, nuclear envelope |
| Protein Family | Annexin family |
Annexin A11 is a member of the annexin family of calcium-dependent phospholipid-binding proteins. The protein consists of four annexin repeats, each comprising a conserved core domain that binds calcium and phospholipids. ANXA11 also contains an N-terminal domain with a prion-like domain that mediates protein-protein interactions.
Annexin A11 participates in various cellular processes:
ANXA11 mutations cause autosomal dominant ALS:
ANXA11 variants are risk factors for PSP:
| Variant | Disease | Mechanism |
|---|---|---|
| G38R | ALS | Disrupted calcium binding |
| A71T | ALS | Impaired autophagy |
| D40G | ALS | TDP-43 mislocalization |
| R235Q | ALS | Aggregate formation |
Annexin A11 in disease:
The study of Annexin A11 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
Toth RP, et al. (2021). Cell Mol Neurobiol. 2021. ↩︎