The androgen receptor (AR) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. It mediates the effects of testosterone and dihydrotestosterone. In the nervous system, AR regulates neuronal survival, neuroprotection, and motor neuron function. CAG repeat expansions cause spinal and bulbar muscular atrophy (SBMA).
Androgen Receptor Protein is encoded by the AR gene. It is a Nuclear receptor, ligand-activated transcription factor with a molecular weight of approximately 405 aa. The protein localizes to Nucleus, Cytoplasm.
The Androgen Receptor Protein contains characteristic domains for its function as a Nuclear receptor, ligand-activated transcription factor. Structural information is available from UniProt and the PDB.
The androgen receptor (AR) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. It mediates the effects of testosterone and dihydrotestosterone. In the nervous system, AR regulates neuronal survival, neuroprotection, and motor neuron function. CAG repeat expansions cause spinal and bulbar muscular atrophy (SBMA).
Dysfunction of Androgen Receptor Protein has been implicated in several neurodegenerative diseases:
Research into therapeutic modulation of Androgen Receptor Protein includes: