The androgen receptor (AR) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. It mediates the effects of testosterone and dihydrotestosterone. In the nervous system, AR regulates neuronal survival, neuroprotection, and motor neuron function. CAG repeat expansions cause spinal and bulbar muscular atrophy (SBMA).
Androgen Receptor Protein is encoded by the AR gene. It is a Nuclear receptor, ligand-activated transcription factor with a molecular weight of approximately 405 aa. The protein localizes to Nucleus, Cytoplasm. [1]
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The Androgen Receptor Protein contains characteristic domains for its function as a Nuclear receptor, ligand-activated transcription factor. Structural information is available from UniProt and the PDB. [3]
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The androgen receptor (AR) is a ligand-activated transcription factor belonging to the nuclear receptor superfamily. It mediates the effects of testosterone and dihydrotestosterone. In the nervous system, AR regulates neuronal survival, neuroprotection, and motor neuron function. CAG repeat expansions cause spinal and bulbar muscular atrophy (SBMA). [5]
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Dysfunction of Androgen Receptor Protein has been implicated in several neurodegenerative diseases: [7]
Research into therapeutic modulation of Androgen Receptor Protein includes:
Androgen Receptor expression data available from the Allen Brain Atlas:
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Querfurth HW, Lee HK. Mammalian targets of rapamycin (mTOR) signaling in the nervous system. 2014. ↩︎
Blurton-Jones M, LaSpada AR. Triplet repeats: neuronally relevant mechanisms in Huntington's disease. 2001. ↩︎
Reddy PH, Williams M, Tagle DA. Recent advances in understanding the molecular genetic basis of neurodegenerative diseases. 1999. ↩︎
Pandey MK, DeGrado TR. Androgen Receptor-Targeted Imaging in Prostate Cancer: Novel Radioligands and PET Tracers. 2016. ↩︎
Michelsen KA, Prickaerts J, Steinbusch HW. The dorsal raphe nucleus and serotonin: implications for neuroplasticity linked to cardiovascular disease. 2006. ↩︎
Brosnan JS, Jacob L. The role of the androgen receptor in the development of Parkinson's disease. 2015. ↩︎