Alpha Synuclein Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
Alpha Synuclein Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Alpha-synuclein Protein | |
|---|---|
| Protein Name | Alpha-synuclein (α-syn) |
| Gene | SNCA |
| UniProt ID | P37840 |
| PDB IDs | 1XQ8, 2J55, 5A2A, 6CU7 |
| Molecular Weight | 14.5 kDa (140 aa) |
| Subcellular Localization | Presynaptic terminals, nucleus, mitochondria |
| Protein Family | Synuclein family |
Alpha-synuclein is a small, natively unfolded protein with three domains:
Alpha-synuclein is the major component of Lewy bodies:
| Approach | Status | Description |
|---|---|---|
| Anti-α-syn antibodies | Clinical trials | Clear aggregated protein |
| Small molecule inhibitors | Research | Prevent aggregation |
| Gene therapy | Research | Reduce SNCA expression |
| α-syn vaccines | Research | Active immunization |
| Neuroprotective agents | Research | Enhance cellular defenses |
Alpha Synuclein Protein plays an important role in the study of neurodegenerative diseases. This page provides comprehensive information about this topic, including its mechanisms, significance in disease processes, and therapeutic implications.
The study of Alpha Synuclein Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.