Aim2 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The AIM2 Protein is a protein involved in various cellular processes relevant to neurodegenerative diseases. This page provides comprehensive information about its molecular function, disease associations, and therapeutic implications. [1]
| AIM2 Protein | |
|---|---|
| Gene | AIM2 |
| UniProt ID | Q9WZE6 |
| PDB IDs | 6B7B |
| Molecular Weight | 39 kDa |
| Subcellular Localization | Cytoplasm |
| Protein Family | AIM2-like receptor (ALR) |
AIM2 (Absent in Melanoma 2) is a cytosolic DNA sensor that forms the AIM2 inflammasome, activating caspase-1 in response to foreign or self DNA.
AIM2 contains two key domains:
HIN Domain (C-terminal):
PYD Domain (N-terminal):
Full-length Structure:
AIM2 functions as a cytosolic DNA sensor forming the AIM2 inflammasome.
Activation Mechanism:
Downstream Effects:
ALS:
Autoimmune Diseases:
Therapeutic Targeting:
Research Tools:
The study of Aim2 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.