¶ ADAM23 Protein (ADAM Metallopeptidase Domain 23)
[^1]
| Property | Value | [^2]
|---------|-------| [^3]
| **Protein Name** | ADAM23 | [^4]
| **Gene** | [ADAM23](/genes/adam23) | [^5]
| **UniProt ID** | [Q9UKP4](https://www.uniprot.org/uniprot/Q9UKP4) |
| **Molecular Weight** | ~100 kDa |
| **Subcellular Localization** | Plasma membrane |
| **Protein Family** | ADAM (A Disintegrin And Metalloproteinase) family |
ADAM23 is a protein encoded by the ADAM23 gene that adam23 is a catalytically-inactive adam protein:. This page describes its structure, normal nervous system function, role in neurodegenerative disease, and potential as a therapeutic target.
ADAM23 is a member of the ADAM (A Disintegrin and Metalloproteinase) family:
- N-terminal signal peptide: Targets protein for secretion
- Prodomain: Keep enzyme inactive until activation
- Metalloproteinase domain: Catalytic activity
- Disintegrin domain: Mediates cell-cell adhesion
- Cysteine-rich region: Additional adhesion functions
- EGF-like domain: Protein-protein interactions
- Transmembrane domain: Cell membrane anchoring
- Cytoplasmic tail: Intracellular signaling
ADAM23 is a catalytically-inactive ADAM protein:
- Cell adhesion: Mediates cell-cell interactions through disintegrin domain
- Neuronal development: Important for neuronal migration and axon guidance
- Synaptogenesis: Involved in synapse formation
- Cancer biology: Tumor suppressor in some cancers
- Evidence: Reduced expression in AD brains
- Mechanism: May affect synaptic function and neuronal viability
- Evidence: Mutations cause familial epilepsy
- Mechanism: Altered neuronal excitability
- Evidence: Tumor suppressor in breast, brain tumors
- Mechanism: Inhibits cell migration and invasion
- ADAM23 in neuronal development (2005)
- ADAM23 as tumor suppressor (2008)
== References ==