ADAM12 (A Disintegrin and Metalloproteinase 12) is a member of the ADAM family that functions both as a metalloprotease and an adhesion molecule[1]. It exists in two isoforms: ADAM12-L (membrane-bound) and ADAM12-S (soluble form generated by alternative splicing)[2].
ADAM12 plays critical roles in:
Stone AL, Kroeger M, Sang QX. Structure-function analysis of the ADAM family of metalloproteinases. 2013. ↩︎
Gilpin BJ, Loechel F, Mattei MG, Engvall E, Albrechtsen R, Wewer UM. A novel, secreted form of human ADAM 12 (meltrin alpha) provokes myogenesis in vivo. 1998. ↩︎
Hinkle CC, Harp J, Yu M, et al. ADAM12 is upregulated by PS2 mutation and its soluble form is detected in plasma and brain. 2009. ↩︎