Acsl4 Protein is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) is an enzyme that catalyzes the conversion of long-chain fatty acids to their active CoA esters. ACSL4 has gained significant attention in neurodegeneration research due to its role in ferroptosis, a form of non-apoptotic cell death characterized by iron-dependent lipid peroxidation. The enzyme is highly expressed in the brain and is implicated in Alzheimer's disease, Parkinson's disease, and Huntington's disease.
| Property | Value |
|---|---|
| Protein Name | ACSL4 (Acyl-CoA Synthetase Long Chain Family Member 4) |
| Gene Symbol | ACSL4 |
| Chromosomal Location | Xq22.3 |
| UniProt ID | O60488 |
| Molecular Weight | ~79 kDa |
| Protein Length | 672 amino acids |
| Subcellular Localization | Endoplasmic reticulum, peroxisomes |
| Strategy | Approach | Status |
|---|---|---|
| ACSL4 Inhibitors | Triacsin C | Research |
| Ferroptosis Inhibitors | Ferrostatin-1, Liproxstatin-1 | Preclinical |
| Iron Chelators | Deferoxamine | Approved |
ACSL4 is being explored for its role in ferroptosis and neuroprotection strategies.
ACSL4 inhibition may provide neuroprotection through ferroptosis modulation. ACSL4 inhibitors are being optimized for clinical development.## References
The study of Acsl4 Protein has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
[1] Research on this topic.