NeuroWiki Work Queue is a topic within the NeuroWiki knowledge base covering aspects of neurodegenerative disease research and mechanisms.
Last Updated: 2026-03-21 08:04 PT
Total Open Tasks: 74
| Priority | Type | Title | Spec |
|---|---|---|---|
| P0 | CI | Pull recent publications | View |
| P0 | CI | Deepen existing pages | View |
| P0 | CI | Expand wiki coverage | View |
| P0 | CI | Quest for Cures — therapeutic ideas pipeline | View |
| P0 | CI | Quest: Knowledge Graph Density — cross-link and connect | View |
| P0 | CI | Quest: Evidence Depth — deepen thin pages to 3000+ words | View |
| P0 | CI | Quest: Emerging Research — track cutting-edge discoveries | View |
| P0 | CI | Quest: Conference Intelligence — crawl and capture conference content | View |
| P0 | CI | Quest AD: Mechanisms — map all Alzheimer's molecular pathways | View |
| P0 | CI | Quest AD: Clinical Trials — track all AD therapeutic trials | View |
| P0 | CI | Quest PD: Mechanisms — map all Parkinson's molecular pathways | View |
| P0 | CI | Quest PD: Clinical Trials — track all PD therapeutic trials | View |
| P0 | CI | Quest CBS: Mechanisms — map corticobasal degeneration pathways | View |
| P0 | CI | Quest PSP: Mechanisms — map PSP molecular pathways | View |
| P0 | CI | Run wiki quality review | View |
| P0 | CI | Fix top loss maker | View |
| P0 | CI | Fix page corruption | View |
| P0 | CI | Strategic task planning | View |
| P0 | CI | Quest: Mechanistic Models — build pathway and interaction maps | View |
| P0 | CI | Quest: Clinical Translation — bridge bench to bedside | View |
| P0 | CI | Quest: Experiment Design — generate, cost, and rank experiments | View |
| P0 | CI | Quest: Living Index Pages — keep rankings and indexes current | View |
| P0 | CI | Quest AD: Companies & Organizations — track AD therapeutic landscape | View |
| P0 | CI | Quest AD: Hypotheses & Evidence — generate and rank AD hypotheses | View |
| P0 | CI | Quest PD: Companies — track PD therapeutic landscape | View |
| P0 | CI | Quest PD: Hypotheses — generate and rank PD hypotheses | View |
| P0 | CI | Quest CBS: Clinical Trials & Treatments — track CBS therapeutic efforts | View |
| P0 | CI | Quest CBS: Evidence Synthesis — deepen CBS understanding | View |
| P0 | CI | Quest PSP: Clinical Trials — track PSP therapeutic pipeline | View |
| P0 | CI | Quest PSP: Evidence Synthesis — comprehensive PSP knowledge | View |
| P0 | CI | Quest 4R-Tauopathies: Shared Tau Biology — CBS/PSP/other 4R-tau diseases | View |
| P0 | CI | Quest PSP: Gender Differences in PSP - male apathy phenotype | View |
| P1 | CI | Run entity linker | View |
| P1 | CI | Fix page queue | View |
| P1 | CI | Link entities to Allen Brain Atlas | View |
| P1 | CI | Improve cross-linking | View |
| P1 | CI | Deduplicate wiki pages | View |
| P1 | CI | Quest: Disease Comparisons — map shared and unique mechanisms | View |
| P1 | CI | Quest: Entity Discovery — systematically find and create missing pages | View |
| P1 | CI | Quest AD: Biomarkers — track diagnostic and prognostic markers | View |
| P1 | CI | Quest PD: Technologies — track PD-specific therapeutic technologies | View |
| P1 | CI | Quest CBS: Diagnostics — track CBS/CBD diagnostic advances | View |
| P1 | CI | Quest PSP: Research Community — track PSP researchers, orgs, funding | View |
| P1 | CI | Quest: Shared Therapeutic Targets — identify cross-disease opportunities | View |
| P1 | CI | Create gene pages | View |
| P1 | CI | Create protein pages | View |
| P1 | CI | CI: Smart task prioritizer — rank queue with explore/exploit | View |
| P1 | CI | CI: Entity tracker — systematic company and technology coverage | View |
| P1 | CI | CI: Page quality ranker — score and rank all wiki pages | View |
| P1 | CI | CI: Section health monitor — track per-section quality metrics | View |
| P1 | CI | Review and update research gaps | View |
| P1 | CI | Create Korean PD Biotech Company Pages | View |
| P1 | CI | Create Digital Health PD Wearables Pages | View |
| P2 | CI | Update with recent publications | View |
| P2 | CI | Fix broken links | View |
| P2 | CI | Scan and queue issues | View |
| P2 | One-shot | Deep dive: Anti-tau immunotherapy programs | View |
| P2 | One-shot | Deep dive: AAV gene therapy for Parkinson's | View |
| P2 | One-shot | Deep dive: ASO therapies for tau reduction | View |
| P2 | One-shot | Process page suggestions | View |
| P2 | CI | Update All Pages index | View |
| P2 | CI | Proofread pages for formatting | View |
| P2 | CI | Verify navigation & index pages | View |
| P2 | CI | Update R&D investment landscape | View |
| P2 | CI | Therapy invention freshness | View |
| P2 | CI | Knowledge gap freshness | View |
| P2 | CI | Cell type atlas freshness | View |
| P2 | One-shot | CI: Update Work Queue Dashboard | View |
| P3 | CI | Task queue and wiki health check | View |
| P3 | One-shot | Update Work Queue Dashboard | View |
| P3 | CI | Create researcher pages | View |
| P3 | CI | Create institution pages | View |
| P3 | CI | Expand short researcher pages | View |
| P3 | One-shot | Create biomarker page: Skin Biopsy Tau Seeding in CBS/PSP | View |
018259fd-7803-4832-b139-9eccd6281ce8Description: Pull recent publications from neuroscience researchers and update relevant wiki pages.
d3cf8645-42bc-4028-b93e-96e0c986e768Description: Deepen existing pages - PRIORITY. Focus on pages <500 words, especially core proteins. Target 2000+ words per page.
6578c64f-ae02-4f98-9d6b-a1e38ef6978fDescription: Daily bot evolution cycle. Last run: 2026-03-20 05:18 PT - +$734.08 PnL (1736 trades, 120 bots), promotion gate OPEN, drift PASS
7d6670f6-149c-49f6-8f22-4ef6dae730d9Description: Maintain 100+ ranked therapeutic hypotheses for neurodegeneration. Each cycle: review existing ideas, identify gaps, CREATE 1-2 new therapeutic idea pages via wiki API with 10-dimension rubric scoring. Must create at least 1 new orchestra task per cycle. Spec: docs/planning/specs/quest_cures_therapeutic_ideas
0de87bd7-a95c-4724-a118-45559558bb94Description: Increase wiki knowledge graph density. Each cycle: find 5 poorly-connected pages (few inbound/outbound links), add cross-links, create missing entity pages, link to related pathways/diseases/proteins. Must CREATE 1-2 new tasks for pages that need creation or deep expansion. Use entity_linker.py to find gaps. Target: every page should have 10+ outbound links.
d8a13fc8-452c-4004-b40b-59b4b28bdbe5Description: Find and deepen the thinnest wiki pages. Each cycle: query wiki for pages under 1000 words in key sections (entities/, mechanisms/, diseases/), pick the 1-2 most important ones, expand to 3000+ words with 20+ PubMed references. Must CREATE 1 task for the next batch of thin pages to expand. Track progress in spec.
e221bc13-f395-45cd-ba76-161632c3c771Description: Systematically track emerging research in neurodegeneration from multiple sources. Each cycle: (1) Crawl Alzforum (alzforum.org) news, research news, therapeutics database for new findings. (2) Check recent high-impact publications on PubMed (2024-2026). (3) Track conference proceedings (AD/PD, AAIC, SfN, CTAD) for new abstracts, posters, talks. (4) Identify novel targets, mechanisms, biomarkers, therapeutic approaches not yet in wiki. (5) CREATE 2-3 new tasks: pages for new discoveries, conference coverage, company/org updates. Use WebFetch to crawl sources. Create pages under appropriate sections (entities/, mechanisms/, treatments/, etc.) with dense cross-linking.
197f9303-cfcd-4045-b902-5a4dca1c6037Description: Systematically crawl major neurodegeneration conferences and capture all content in the wiki. Target conferences: AD/PD (adpd.kenes.com), AAIC (aaic.alz.org), CTAD (ctad-alzheimer.com), SfN Annual Meeting, AAN Annual Meeting, World Parkinson Congress, International Congress on Parkinson's Disease. Each cycle: (1) WebFetch conference websites for programs, abstracts, poster listings, speaker lists, sponsor/exhibitor lists. (2) Create/update pages under events/{conference-slug}/ for each conference. (3) Create pages for notable talks, poster highlights, key findings. (4) Create/update pages for companies and organizations presenting. (5) Cross-link to existing mechanism/disease/treatment pages. (6) CREATE 2-3 tasks for specific conference content to capture. Track all conferences in an events/conference-index page.
3a885889-6c19-4103-8e31-1582eb34a828Description: Systematically map ALL Alzheimer's molecular pathways with zero bias toward any single hypothesis. Each cycle: (1) Query wiki for AD mechanism pages, rank by completeness (word count, refs, cross-links). (2) Identify the LEAST covered mechanism — not the most popular one. (3) WebSearch PubMed for recent reviews on that mechanism to ensure coverage reflects current evidence weight, not historical prominence. (4) CREATE 2-3 tasks to fill gaps. IMPORTANT: Do NOT fixate on amyloid/tau — equally cover lipid metabolism, vascular, immune, metabolic, infectious, epigenetic, RNA, proteostasis, and any novel hypotheses. The ranking page should weight mechanisms by: number of supporting publications, clinical trial activity, genetic evidence strength, and recency of discoveries. Maintain mechanisms/ad-mechanism-index with evidence-weighted rankings.
deecb135-3702-4246-b05f-c17e29b429f5Description: Track ALL active AD clinical trials without bias toward any mechanism or company. Each cycle: (1) WebFetch clinicaltrials.gov searching 'Alzheimer' — include recruiting, active, and recently completed. (2) Categorize by mechanism class — do NOT pre-filter. Include: novel mechanisms, repurposed drugs, combinations, non-pharmacological, biomarker studies, prevention, lifestyle interventions. (3) Identify trials NOT yet in wiki — prioritize by phase, enrollment, and novelty of approach over company prominence. (4) CREATE 2-3 tasks. Rank trials by evidence strength and potential impact, not sponsor size.
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