title: National Institutes of Health (NIH)
description: "# National Institutes of Health (NIH)
The National Institutes of Health (NIH) is the primary agency of the United States government responsible for biomedical and public health research. With 27 institutes and centers, the NIH is the largest source of medical research funding in the world.
¶ National Institute of Neurological Disorders and Stroke (NINDS)
NINDS is the primary NIH institute funding PSP research:
- PSP research grants: Funds basic and clinical research on PSP pathophysiology, biomarkers, and therapeutic targets
- Clinical trials: Supports clinical trials for PSP therapeutics through the NINDS Clinical Trials Network
- Training programs: Supports career development for early-career researchers in movement disorders
The NIA funds research on:
- Tauopathies and aging-related neurodegeneration
- Alzheimer's disease and related dementias (PSP is sometimes included)
- Biomarker development for neurodegenerative diseases
While primarily focused on mental health, NINIM funds research on:
- Neuropsychiatric symptoms in neurodegenerative diseases
- Behavioral interventions
The NIH funds the Tau Consortium, a collaborative research effort focusing on:
- Tau biology and pathology
- Development of tau-targeted therapies
- Biomarker validation
NIH funding supports:
- Parkinson's Progression Markers Initiative (PPMI): Includes PSP subjects
- Dominantly Inherited Alzheimer Network (DIAN): Relevant for tau research
- Alzheimer's Disease Neuroimaging Initiative (ADNI): Biomarker development
- R01: Research Project Grants - investigator-initiated research
- R21: Exploratory/Developmental Grants - innovative ideas
- U01: Research Cooperative Agreements - collaborative research
- P50: Specialized Centers - multi-project research programs
- K99/R00: Career Development Awards - early-career researchers
- Rare Diseases Research: PSP qualifies for NIH Office of Rare Diseases Research programs
- Precision Medicine Initiative: Includes neurodegenerative disease components
The NIH has been critical in advancing PSP research:
- Funding basic research on 4R tau biology
- Supporting clinical trial infrastructure
- Enabling biomarker development
- Training the next generation of PSP researchers
Many leading PSP researchers receive NIH funding, including: