This page is linked to Alzheimer's disease, tau pathology, amyloid cascade, neuroinflammation, mitochondrial dysfunction, protein aggregation, autophagy, oxidative stress, and blood-brain barrier.
Alzheimer's Disease Mechanism Index describes a key molecular or cellular mechanism implicated in neurodegenerative disease. This page provides a detailed overview of the pathway components, signaling cascades, and their relevance to conditions such as Alzheimer's disease, Parkinson's disease, and related disorders.
Last Updated: 2026-03-21 PT
This index ranks AD molecular mechanisms by completeness (word count), evidence (references), and connectivity (cross-links). Priority should be given to mechanisms with lower scores to expand coverage.
The quality score is calculated as: (word_count / 100) + (references * 2) + (links / 10)
| Rank |
Mechanism |
Words |
Refs |
Links |
Score |
| 1 |
Biomarkers of Alzheimer Disease |
4732 |
91 |
169 |
246.2 |
| 2 |
AD Biomarker-to-Mechanism Mapping |
3074 |
38 |
80 |
114.7 |
| 3 |
Insulin Resistance and Metabolic Dysfunction in Alzheimer's |
3108 |
34 |
109 |
110.0 |
| 4 |
Tau Pathology |
3666 |
27 |
111 |
101.8 |
| 5 |
Neuroinflammation in Alzheimer's Disease |
2295 |
33 |
58 |
94.8 |
| 6 |
Amyloid Cascade Pathway |
3267 |
22 |
122 |
88.9 |
| 7 |
Blood-Brain Barrier Breakdown in Alzheimer's |
2516 |
26 |
108 |
88.0 |
| 8 |
Familial Alzheimer's Disease Genetics |
1989 |
29 |
100 |
87.9 |
| 9 |
NAD+ Metabolism in Neurodegeneration |
2499 |
26 |
85 |
85.5 |
| Rank |
Mechanism |
Words |
Refs |
Links |
Score |
| 10 |
4R Tauopathy Molecular Mechanisms |
3065 |
20 |
104 |
81.1 |
| 11 |
Tau Pathology in Alzheimer's Disease |
2227 |
25 |
49 |
77.2 |
| 12 |
Tauopathy |
2431 |
18 |
100 |
70.3 |
| 13 |
Shared Mechanisms Between Alzheimer and Parkinson |
2445 |
20 |
56 |
70.0 |
| 14 |
Tau Seeding and Propagation Pathway |
2136 |
20 |
55 |
66.9 |
| 15 |
Tau Pathology Pathway |
3085 |
12 |
81 |
63.0 |
| 16 |
Cortisol-Tau Pathway |
4615 |
0 |
164 |
62.5 |
| 17 |
Gut-Brain Axis in Tauopathy |
4199 |
6 |
74 |
61.4 |
| 18 |
Metal Ion Homeostasis in Alzheimer's |
1858 |
18 |
44 |
59.0 |
| 19 |
Sex-Specific Mechanisms in Alzheimer's |
1588 |
16 |
71 |
55.0 |
The following mechanisms are linked to Alzheimer's disease, tau pathology, neuroinflammation, and mitochondrial dysfunction:
| Rank |
Mechanism |
Words |
Refs |
Links |
Score |
Priority |
| 20 |
Amyloid-Tau Synergistic Interaction |
987 |
1 |
21 |
14.0 |
Medium |
| 21 |
LRP1-Mediated Amyloid-Beta Clearance |
913 |
1 |
28 |
13.9 |
Medium |
| 22 |
AD Biomarker Temporal Sequence Hypothesis |
956 |
1 |
23 |
13.9 |
Medium |
| 23 |
Mitochondrial Dysfunction: AD vs PD vs ALS |
475 |
4 |
10 |
13.8 |
High |
| 24 |
Neuroinflammation in AD and PD |
1002 |
0 |
32 |
13.2 |
High |
| 25 |
Cerebral Amyloid Angiopathy Mechanism |
1046 |
0 |
22 |
12.7 |
Medium |
| 26 |
Amyloid Oligomers in Neurodegeneration |
930 |
1 |
13 |
12.6 |
Medium |
| 27 |
Synaptic Dysfunction in Alzheimer's Disease |
901 |
0 |
20 |
11.0 |
High |
| 28 |
TYROBP/DAP12 Microglia Signaling |
937 |
0 |
15 |
10.9 |
High |
| 29 |
Amyloid Pathology |
400 |
2 |
15 |
9.5 |
Critical |
The following AD-relevant mechanism categories have no dedicated AD-specific pages:
-
RNA Metabolism in AD — Task Created
-
Infectious Etiology Hypotheses in AD — Task Created
-
Ubiquitin-Proteasome System in AD — Task Created
-
Apoptosis Pathways in AD — Task Created
-
Necrosis/Regulated Necroptosis in AD — Task Created
-
Autophagy-Lysosomal System (AD-specific) — Page exists: Autophagy-Lysosomal Pathway Dysfunction in AD
-
Create Glymphatic System in Alzheimer's Disease (Task aac0bbbb) — Create AD-specific page with 20+ refs
-
Create Calcium Signaling Dysregulation in AD (Task 2f819972) — Create AD-specific page with 20+ refs
- Expand SYK Microglial Activation Alzheimer's — Add 20+ References (Task 014ddf8a-0d1) — Add hyperlinked PMID/DOI refs to syk-microglial-activation-alzheimers.md (currently 1880 words, 10 hyperlinked refs)
- Expand Geniposide Alzheimer's Mechanism — Add 20+ References (Task 55eb2f91-8fe) — Add hyperlinked PMID/DOI refs to geniposide-alzheimers-mechanism.md (currently 2697 words, 22 hyperlinked refs)
- Expand APOE4 Alzheimer's — Add 20+ References (Task 7615e996-beb) — Add hyperlinked PMID/DOI refs to apoe4-alzheimers.md (currently 2183 words, 26 hyperlinked refs)
Created 2026-03-28 22:15 PT
Analyzed current mechanism coverage: Many formerly-missing mechanisms now have substantial pages:
Remaining gaps:
- Amyloid Pathology (score 9.5, 400 words, 2 refs, 15 links) — needs expansion
- Synaptic Dysfunction in AD (score 11.0, 901 words, 0 refs, 20 links) — needs references
Assessed 2026-04-01 16:50 PT
- Expand Amyloid Pathology AD — Add 20+ References (Task 5841798c-d6f5) — Add hyperlinked PMID/DOI refs to amyloid-pathology.md (currently 400 words, 2 refs, 15 links, score 9.5)
- Expand Synaptic Dysfunction AD — Add 20+ References (Task febd2885-899b) — Add hyperlinked PMID/DOI refs to synaptic-dysfunction-ad.md (currently 901 words, 0 refs, 20 links, score 11.0)
Created 2026-04-01 16:50 PT
- Tanshinone IIA-Pretreated MSC Therapy for AD — Added 12 hyperlinked PubMed references to body text, standardized reference format, added 12 references to References section. Page now 1275 words, 24 hyperlinked refs, score improved from 12.1 to 61.5.
Completed 2026-03-29 09:15 PT
- Synaptic Loss in Alzheimer's Disease Pathway — Fixed broken reference sections (3 duplicate ## References headers with "Unknown (n.d.)" entries), repaired truncated section headers, fixed broken bullet points, cleaned trailing citekey garbage. Added 22 hyperlinked PMID references. Page now 3056 words, 22 hyperlinked refs, 25 citekeys. Score improved from 5 to 50+.
Completed 2026-03-28 23:17 PT
- Expand CBS/PSP Cure Roadmap — Add 20+ References (Task 7354827a-4c5b) — Add hyperlinked PMID/DOI refs to cbs-psp-cure-roadmap.md (currently 1815 words, 5 hyperlinked refs)
- Expand Gut-Brain Axis in Alzheimer's — Add 15+ References (Task eb12f0ad-3a67) — Add hyperlinked PMID/DOI refs to gut-brain-axis-ad.md (currently 1833 words, 8 hyperlinked refs)
- Expand PSEN1 Presenilin 1 AD Causal Chain — Add 15+ References (Task 5a0e2f75-d81) — Add hyperlinked PMID/DOI refs to psen1-presenilin-1-ad-causal-chain.md (currently 1412 words, 7 hyperlinked refs)
Created 2026-03-28 20:53 PT
- Expand AD-PD Shared Pathways — Add 20+ References (Task f4037ef1-a0a) — Add hyperlinked PMID/DOI refs to ad-pd-shared-pathways.md (currently 2791 words, 0 hyperlinked refs)
- Expand AD Cure Roadmap — Add 20+ References (Task 7f0696b7-bac) — Add hyperlinked PMID/DOI refs to ad-cure-roadmap.md (currently 3487 words, 2 hyperlinked refs)
- Expand AD Neuroinflammation Microglia Pathway — Add 20+ References (Task 3887bffe-367) — Add hyperlinked PMID/DOI refs to ad-neuroinflammation-microglia-pathway.md (currently 2078 words, 2 hyperlinked refs)
- Expand AD Knowledge Gaps Ranked — Add 20+ References (Task d2a95ca0-801) — Add hyperlinked PMID/DOI refs to ad-knowledge-gaps-ranked.md (currently 1887 words, 7 hyperlinked refs)
- Expand Reactive Astrogliosis — Add 20+ References (Task 917ff464-542) — Add hyperlinked PMID/DOI refs to reactive-astrogliosis.md (currently 2384 words, 5 citekeys)
Created 2026-03-28 19:05 PT
- Expand NRTI Immunomodulation in Alzheimer's — Add 20+ References (Task fdee2ef5-3aa) — Add hyperlinked PMID/DOI refs to nrti-immunomodulation-alzheimers.md (currently 2388 words, 8 hyperlinked refs)
- Expand Geniposide Alzheimer's Mechanism — Add 20+ References (Task 395decf8-840) — Add hyperlinked PMID/DOI refs to geniposide-alzheimers-mechanism.md (currently 2551 words, 8 hyperlinked refs)
- Expand EEG Microstates in Alzheimer's — Add 20+ References (Task c7c408d2-bd8) — Add hyperlinked PMID/DOI refs to eeg-microstates-alzheimers.md (currently 3353 words, 16 hyperlinked refs)
¶ Expanded Referenced Mechanisms (2026-03-28 18:34 PT) — Slot 2
- Familial Alzheimer's Genetics — Added 40 hyperlinked references (PMIDs/DOIs) — Score improved from 0 to 80+
- NRTI Immunomodulation in Alzheimer's — Added 30 hyperlinked references — Score improved from 0 to 60
- Sporadic Alzheimer's Pathway — Added 26 hyperlinked references — Score improved from 5 to 31
Created 2026-03-28 18:00 PT
- Expand SIRT1 Alzheimer Pathway — Add 20+ References (Task f4df0a3d-212f) — Add hyperlinked PMID/DOI refs to sirt1-alzheimer-pathway.md (currently 3119 words, 0 hyperlinked refs)
- Expand Ferroptosis in Alzheimer's Disease — Add 20+ References (Task ebea9dbd-818d) — Add hyperlinked PMID/DOI refs to ferroptosis-alzheimers.md (currently 3033 words, 0 hyperlinked refs)
Created 2026-03-28 17:28 PT
- Expand PSEN1 Presenilin 1 AD Causal Chain — Add 15+ References (Task 15469779-092) — Add hyperlinked PMID/DOI refs to psen1-presenilin-1-ad-causal-chain.md (currently 1391 words, 7 broken refs)
- Expand BBB Dysfunction AD PD ALS Comparison — Add 15+ References (Task ae6616cb-50a) — Add hyperlinked PMID/DOI refs to bbb-dysfunction-comparison-ad-pd-als.md (currently 2701 words, 14 refs)
Created 2026-03-28 17:06 PT
Created 2026-03-28 15:55 PT
- Expand Sex-Specific Mechanisms in Alzheimer's — Add 20+ References (Task 75165125) — Add hyperlinked PMID/DOI refs to sex-specific-mechanisms-alzheimers.md (currently 1845 words, 0 hyperlinked refs)
- Expand Neuronal Network Dysfunction in Alzheimer's — Add 20+ References (Task 0f740efe) — Add hyperlinked PMID/DOI refs to neuronal-network-dysfunction-alzheimers.md (currently 1875 words, 0 hyperlinked refs)
- Expand Glymphatic System in Alzheimer's — Add 20+ References (Task a2650d38) — Add hyperlinked PMID/DOI refs to glymphatic-system-alzheimers.md (currently 1886 words, 0 hyperlinked refs)
Created 2026-03-28 14:15 PT
- Expand Daphnetin KCC2 Alzheimer's — Add 15+ References (Task 963eed87) — Add hyperlinked PMID/DOI refs to daphnetin-kcc2-alzheimers.md (currently 1864 words, 1 hyperlinked ref)
- Expand Familial Alzheimer's Genetics — Add 20+ References (Task 99249024) — Add hyperlinked PMID/DOI refs to familial-alzheimers-genetics.md (currently 4187 words, 1 hyperlinked ref)
- Expand Sporadic Alzheimer's Pathway — Add 20+ References (Task 097aa444) — Add hyperlinked PMID/DOI refs to sporadic-alzheimers-pathway.md (currently 3013 words, 5 hyperlinked refs)
Created 2026-03-28 13:25 PT
- Expand Synaptic Loss AD Pathway — Add 20+ References (Task c4b0c7ab) — Add 20+ peer-reviewed refs to synaptic-loss-ad-pathway.md (currently 3152 words, 0 hyperlinked refs)
- Expand Retrograde Transport Endosomal Pathway — Add 20+ References (Task 7626b73d) — Add 20+ peer-reviewed refs to retrograde-transport-endosomal-pathway.md (currently 1869 words, 3 hyperlinked refs)
- Expand Noradrenergic Signaling Neurodegeneration — Add 20+ References (Task 2f011bf7) — Add 20+ peer-reviewed refs to noradrenergic-signaling-neurodegeneration.md (currently 1926 words, 4 hyperlinked refs)
Created 2026-03-28 13:10 PT
- Expand Sleep and Circadian Dysfunction in Alzheimer's — Add 20+ References (Task 6d07f3d6) — Add 20+ peer-reviewed refs to sleep-circadian-dysfunction-alzheimers.md (currently 5573 words, 0 hyperlinked refs)
- Expand Cellular Senescence in Alzheimer's — Add 20+ References (Task f9a7ae24) — Add 20+ peer-reviewed refs to cellular-senescence-alzheimers.md (currently 4517 words, 0 hyperlinked refs)
- Expand Autophagy-Lysosomal Pathway in Alzheimer's — Add 20+ References (Task ba3d567e) — Add 20+ peer-reviewed refs to autophagy-lysosomal-alzheimers.md (currently 3786 words, 0 hyperlinked refs)
Created 2026-03-28 01:50 PT
- Expand AD Prevention vs Treatment — Add 20+ References (Task a7fbdbce) — Add 20+ peer-reviewed refs to ad-prevention-vs-treatment.md (currently 4095 words, 0 hyperlinked refs)
- Expand Neuroinflammation AD — Add 20+ References (Task 4d4a1bbe) — Add 20+ peer-reviewed refs to neuroinflammation-ad.md (currently 4045 words, 0 hyperlinked refs)
- Expand Mitochondrial Dysfunction AD Pathway — Add 20+ References (Task a958defc) — Add 20+ peer-reviewed refs to mitochondrial-dysfunction-ad-pathway.md (currently 3682 words, 0 hyperlinked refs)
Created 2026-03-27 19:35 PT
- Expand APP Amyloid Pathway in Alzheimer's — Add 20+ References (Task be9ee039) — Add 20+ peer-reviewed refs to app-amyloid-pathway-alzheimers.md (currently 3815 words, 1 hyperlinked ref)
Created 2026-03-27 13:12 PT
- Expand APP Amyloid Pathway in Alzheimer's — Add 20+ References (Task 6e12fd9f) — Add 20+ peer-reviewed refs to app-amyloid-pathway-alzheimers.md (currently 3815 words, 1 hyperlinked ref)
- Expand Sporadic Alzheimer's Pathway — Add 20+ References (Task a49ff808) — Add 20+ peer-reviewed refs to sporadic-alzheimers-pathway.md (currently 3013 words, 5 hyperlinked refs)
- Expand Familial Alzheimer's Genetics — Add 20+ References (Task b7c85fb4) — Add 20+ peer-reviewed refs to familial-alzheimers-genetics.md (currently 4187 words, 1 hyperlinked ref)
Created 2026-03-27 13:00 PT
- Expand NLRP3 Inflammasome AD Pathway — Add 20+ References (Task 8c689ab2) — Add 20+ peer-reviewed refs to nlrp3-inflammasome-ad-pathway.md (currently 2302 words, 0 hyperlinked refs)
- Expand cGAS-STING AD Pathway — Add 20+ References (Task b7c60b2f) — Add 20+ peer-reviewed refs to cgas-sting-ad-pathway.md (currently 2384 words, 0 hyperlinked refs)
- Expand Apoptosis in Alzheimer's Disease — Add 20+ References (Task ec024445) — Add 20+ peer-reviewed refs to apoptosis-alzheimers-disease.md (currently 2376 words, 0 hyperlinked refs)
Created 2026-03-27 04:35 PT
- Expand Sporadic Alzheimer's Pathway — Add 20+ References (Task dd8f41cf) — Add 20+ peer-reviewed refs to sporadic-alzheimers-pathway.md (currently 2453 words, 0 hyperlinked refs)
- Expand Neuronal Network Dysfunction in Alzheimer's — Add 20+ References (Task a3351c50) — Add 20+ peer-reviewed refs to neuronal-network-dysfunction-alzheimers.md (currently 2401 words, 0 hyperlinked refs)
- Expand Sex-Specific Mechanisms in Alzheimer's — Add 20+ References (Task e5a842ed) — Add 20+ peer-reviewed refs to sex-specific-mechanisms-alzheimers.md (currently 2257 words, 0 hyperlinked refs)
Created 2026-03-27 03:05 PT
- Expand APP Amyloid Beta Plaque AD Causal Chain — Add 20+ References (Task 89c8672f) — Add 20+ peer-reviewed refs to app-amyloid-beta-plaque-ad-causal-chain.md (currently 895 words, 0 hyperlinked refs)
- Expand Tanshinone MSC TREM2 Alzheimer's — Add 20+ References (Task fb89834d) — Add 20+ peer-reviewed refs to tanshinone-msc-trem2-alzheimers.md (currently 906 words, 0 hyperlinked refs)
- Expand AD Combination Therapy Matrix — Add 20+ References (Task b7e157a6) — Add 20+ peer-reviewed refs to ad-combination-therapy-matrix.md (currently 1856 words, 0 hyperlinked refs)
Created 2026-03-27 00:15 PT
- Expand Daphnetin KCC2 in Alzheimer's — Add 20+ References (Task 359d8310) — Add 20+ peer-reviewed refs to daphnetin-kcc2-alzheimers.md (currently 1102 words, 0 hyperlinked refs)
- Expand NRTI Immunomodulation in Alzheimer's — Add 20+ References (Task 57755d01) — Add 20+ peer-reviewed refs to nrti-immunomodulation-alzheimers.md (currently 1713 words, 0 hyperlinked refs)
- Expand Geniposide Alzheimer's Mechanism — Add 20+ References (Task d80e058c) — Add 20+ peer-reviewed refs to geniposide-alzheimers-mechanism.md (currently 1836 words, 0 hyperlinked refs)
Created 2026-03-26 17:48 PT
- Expand AD Glymphatic Clearance Pathway — Add 20+ References (Task 0e0bd3b5) — Add 20+ peer-reviewed refs to ad-glymphatic-clearance-pathway.md (currently 534 words, 0 hyperlinked refs)
- Expand AD Epigenetic Alterations Pathway — Add 20+ References (Task 8c878806) — Add 20+ peer-reviewed refs to ad-epigenetic-alterations-pathway.md (currently 593 words, 0 hyperlinked refs)
- Expand Circadian Dysfunction AD Pathway — Add 20+ References (Task feced104) — Add 20+ peer-reviewed refs to circadian-dysfunction-ad-pathway.md (currently 800 words, 0 hyperlinked refs)
Created 2026-03-26 17:35 PT
- Expand Cellular Senescence in Alzheimer's — Add 20+ References (Task bf46a80b) — Add 20+ peer-reviewed refs to cellular-senescence-alzheimers.md (currently 8317 words, 0 hyperlinked refs)
- Expand Calcium Dysregulation in Alzheimer's — Add 20+ References (Task 065160d7) — Add 20+ peer-reviewed refs to calcium-dysregulation-alzheimers.md (currently 6844 words, 0 hyperlinked refs)
- Expand Sleep-Circadian Dysfunction in Alzheimer's — Add 20+ References (Task ff8109dd) — Add 20+ peer-reviewed refs to sleep-circadian-dysfunction-alzheimers.md (currently 6843 words, 0 hyperlinked refs)
Created 2026-03-26 16:38 PT
- Expand Integrated Stress Response in AD — Deepen to 2000+ words (Task a79043c2) — Expand integrated-stress-response-ad.md from 655 to 2000+ words with additional sections on ISR in different brain cell types, therapeutic targeting, and cross-links to related pathways. Add 20+ peer-reviewed references.
- Expand NLRP3 Inflammasome AD Pathway — Add therapeutic targeting section (Task 7f36df3f) — Expand nlrp3-inflammasome-ad-pathway.md from 750 to 2000+ words. Add sections on NLRP3 inhibitors in clinical trials, microglial phenotype switching, cross-links to TREM2 and tau. Add 20+ peer-reviewed references.
- Expand TREM2 Microglial Dysfunction AD Causal Chain — Add therapeutic strategies (Task d1f01af2) — Expand trem2-microglial-dysfunction-ad-causal-chain.md from 886 to 2000+ words. Add sections on TREM2 agonist development, gene therapy approaches, biomarker applications. Add 20+ peer-reviewed references.
Created 2026-03-26 15:25 PT
Created 2026-03-26 12:05 PT
- Expand Sleep-Circadian Dysfunction in Alzheimer's — Add 20+ References (Task 652c2f07) — Add 20+ peer-reviewed refs to sleep-circadian-dysfunction-alzheimers.md (currently 8024 words, 0 hyperlinked refs)
- Expand Cellular Senescence in Alzheimer's — Add 20+ References (Task 7d2020fb) — Add 20+ peer-reviewed refs to cellular-senescence-alzheimers.md (currently 6813 words, 0 hyperlinked refs)
- Expand Nanomedicine in Alzheimer's Disease — Add 20+ References (Task f082a97d) — Add 20+ peer-reviewed refs to nanomedicine-alzheimers-disease.md (currently 6058 words, 0 hyperlinked refs)
Created 2026-03-26 10:46 PT
- Expand Cellular Senescence in Alzheimer's — Add 20+ References (Task df412362) — Add 20+ peer-reviewed refs to cellular-senescence-alzheimers.md (currently 4310 words, 0 hyperlinked refs)
- Expand APOE Lipid Metabolism in Alzheimer's — Add 20+ References (Task 8f5d325f) — Add 20+ peer-reviewed refs to apoe-lipid-metabolism-alzheimers.md (currently 981 words, 0 hyperlinked refs)
- Expand APOE4 and AD Risk — Add 20+ References (Task 4753cba7) — Add 20+ peer-reviewed refs to apoe4-alzheimers.md (currently 817 words, 0 hyperlinked refs)
Created 2026-03-26 10:22 PT
- Expand Integrated Stress Response in AD — Add 20+ References (Task 8dedca75) — Add 20+ peer-reviewed refs to integrated-stress-response-ad.md (currently 376 words, 0 hyperlinked refs)
- Expand Epigenetic Alterations in AD — Add 20+ References (Task b0cfca73) — Add 20+ peer-reviewed refs to ad-epigenetic-alterations-pathway.md (currently 401 words, 0 hyperlinked refs)
- Expand Circadian Dysfunction in AD — Add 20+ References (Task 21df3bcf) — Add 20+ peer-reviewed refs to circadian-dysfunction-ad-pathway.md (currently 420 words, 0 hyperlinked refs)
Created 2026-03-26 09:50 PT
- Expand AD Experimental Models Scored — Add 20+ References (Task 43affc6c) — Add 20+ peer-reviewed refs to ad-experimental-models-scored.md (currently 1790 words, 0 refs, 0 links)
- Expand NAD Metabolism Pathway in Neurodegeneration — Add 20+ References (Task 9339535e) — Add 20+ peer-reviewed refs to nad-metabolism-pathway-neurodegeneration.md (currently 1406 words, 0 refs, 0 links)
- Expand AD Prevention vs Treatment — Add 20+ References (Task 3445b140) — Add 20+ peer-reviewed refs to ad-prevention-vs-treatment.md (currently 3309 words, 0 refs, 0 links)
Created 2026-03-26 09:32 PT
Created 2026-03-26 07:01 PT
Created 2026-03-26 08:20 PT
Created 2026-03-26 08:35 PT
Created 2026-03-26 06:42 PT
Created 2026-03-26 08:00 PT
- Expand Calcium Signaling in AD — Add 20+ References (Task 43f74aee) — Add 20+ peer-reviewed refs to calcium-signaling-ad.md (currently 760 words, 0 refs)
- Expand Evidence Contradictions Synthesis — Add 20+ References (Task 2e392eb0) — Add 20+ peer-reviewed refs to evidence-contradictions-synthesis.md (currently 577 words, 0 refs)
- Expand AD Hypothesis Comprehensive Analysis — Add 20+ References (Task 9ecf3c18) — Add 20+ peer-reviewed refs to ad-hypothesis-comprehensive-analysis.md (currently 891 words, 0 refs)
Created 2026-03-26 06:13 PT
Created 2026-03-26 06:02 PT
Created 2026-03-26 05:55 PT
- Create Sleep and Circadian Dysfunction in Alzheimer's Disease (Task 5db9e26b) — Create AD-specific page with 20+ refs (sleep architecture, circadian rhythm, glymphatic clearance, orexin system)
- Create DNA Damage Response in Alzheimer's Disease (Task 99301ba8) — Create AD-specific page with 20+ refs (DNA repair deficits, PARP, telomere attrition)
- Expand Amyloid-Tau Synergistic Interaction in AD — Add 20+ References (Task 18f566ff) — Expand from 987 words to 2000+ words with 20+ refs
Created 2026-03-26 04:54 PT
Created 2026-03-26 04:41 PT
- Expand APOE4 and AD Risk — Add 15+ References (Task 32c3c0d0) — Add 15+ peer-reviewed refs to apoe4-alzheimers.md (currently 1316 words, 13 refs)
- Expand Sporadic AD Pathway — Add 15+ References (Task 6d08f9f3) — Add 15+ peer-reviewed refs to sporadic-alzheimers-pathway.md (currently 1477 words, 14 refs)
- Expand Neuronal Network Dysfunction in AD — Add 15+ References (Task 2d420a07) — Add 15+ peer-reviewed refs to neuronal-network-dysfunction-alzheimers.md (currently 1672 words, 16 refs)
Created 2026-03-26 03:47 PT
- Expand Arsenic Alzheimer Mechanism — Add 20+ References (Task 44f2dde7) — Add 20+ peer-reviewed refs to arsenic-alzheimer-mechanism.md (currently 3418 words, 0 hyperlinked refs)
- Expand Metal Homeostasis in Alzheimer's — Add 20+ References (Task 46386e34) — Add 20+ peer-reviewed refs to metal-homeostasis-alzheimers.md (currently 2719 words, 0 hyperlinked refs)
- Expand Monoclonal Antibody Therapy in Alzheimer's — Add 20+ References (Task f2e06037) — Add 20+ peer-reviewed refs to monoclonal-antibody-therapy-alzheimers-disease.md (currently 3045 words, 0 hyperlinked refs)
Created 2026-03-26 03:15 PT
- Expand Cellular Senescence in Alzheimer's — Add 20+ References (Task c2e1547c) — Add 20+ peer-reviewed refs to cellular-senescence-alzheimers.md (currently 4733 words, 0 proper refs)
- Expand Circadian Rhythm Dysfunction in AD — Add 20+ References (Task d832d4e4) — Add 20+ peer-reviewed refs to circadian-rhythm-dysfunction-alzheimers.md (currently 4190 words, 0 proper refs)
- Expand AD Failed Approaches Analysis — Add 20+ References (Task ca85a44d) — Add 20+ peer-reviewed refs to ad-failed-approaches-analysis.md (currently 3858 words, 0 proper refs)
Created 2026-03-26 03:00 PT
- Expand Antibody Therapy in Neurodegeneration — Add 20+ References (Task effe3397) — Add 20+ peer-reviewed refs to antibody-therapy-neurodegeneration.md (currently 2117 words, 0 refs, 18 Alzheimer mentions)
- Expand Perineuronal Nets in Neurodegeneration — Add 20+ References (Task e725a88a) — Add 20+ peer-reviewed refs to perineuronal-nets.md (currently 1818 words, 0 refs, 7 Alzheimer mentions)
- Expand Long-Term Potentiation in Neurodegeneration — Add 20+ References (Task 98441b8e) — Add 20+ peer-reviewed refs to long-term-potentiation.md (currently 1789 words, 0 refs, 5 Alzheimer mentions)
Created 2026-03-26 01:15 PT
- Expand DNA Damage Response in Alzheimer's — Add 20+ References (Task 3ef96afb) — Add 20+ peer-reviewed refs to dna-damage-response-alzheimers.md (currently 3702 words, 0 refs)
- Expand Nanomedicine in Alzheimer's Disease — Add 20+ References (Task db2ca5f0) — Add 20+ peer-reviewed refs to nanomedicine-alzheimers-disease.md (currently 4875 words, 0 refs)
- Expand Epigenetics in Alzheimer's Disease — Add 20+ References (Task 843d646f) — Add 20+ peer-reviewed refs to epigenetics-ad.md (currently 4134 words, 0 refs)
Created 2026-03-26 01:15 PT
Created 2026-03-26 00:56 PT
- Expand Familial Alzheimer's Genetics — Add 20+ References (Task 22d81d55) — Add 20+ peer-reviewed refs to familial-alzheimers-genetics.md (currently 3541 words, 0 refs)
- Expand Vascular Risk Factors in Alzheimer's — Add 20+ References (Task ef6f329f) — Add 20+ peer-reviewed refs to vascular-risk-factors-alzheimers.md (currently 3261 words, 0 refs)
- Expand Neuroinflammation in Alzheimer's — Add 20+ References (Task c2134a95) — Add 20+ peer-reviewed refs to neuroinflammation-ad.md (currently 3482 words, 0 refs)
Created 2026-03-25 19:30 PT
- Expand 3xTG-AD Mouse Model — Add 20+ References (Task 377ebd9d) — Expand from 1036 words to 2000+ words with 20+ peer-reviewed refs
- Expand Proteostasis ERAD Pathway — Add 20+ References (Task 797454ec) — Expand from 1278 words to 2000+ words with 20+ peer-reviewed refs (AD-specific mechanisms)
Created 2026-03-25 14:55 PT
- Expand Neuroinflammation in AD and PD (Task 75afe1ca)
- Expand Ferroptosis in Alzheimer's Disease — Add 20+ References (Task 44adbc85) — Add 20+ peer-reviewed refs to ferroptosis-ad.md (currently 3700 words, 0 refs)
- Expand Neuronal Network Dysfunction in Alzheimer's Disease — Add 20+ References (Task 67eca4b2) — Add 20+ peer-reviewed refs to neuronal-network-dysfunction-alzheimers.md (currently 1006 words, 0 refs)
Created 2026-03-24 22:49 PT
- Create Glymphatic System in Alzheimer's Disease (Task aac0bbbb) — Create AD-specific page with 20+ refs (generic page exists but needs AD-specific version)
- Create Calcium Signaling Dysregulation in AD (Task 2f819972) — Create AD-specific page with 20+ refs (generic page exists but needs AD-specific version)
Created 2026-03-24 16:37 PT
- Create Cholinergic Hypothesis in Alzheimer's Disease (Task 06c431ed) — Expand from 4 words (just redirect) to 2000+ words with 20+ refs
- Expand AD Biomarker Temporal Sequence Hypothesis — Add 20+ References (Task d9941b37) — Add 20+ peer-reviewed refs (currently 1404 words, 0 refs)
Created 2026-03-23 20:10 PT
- Expand Lipid Raft Dysfunction in Neurodegeneration — Add 20+ References (Task 6bdba970) — Add 20+ peer-reviewed refs (currently 0, 545 words)
- Expand JNK/p38 MAPK Signaling in Neurodegeneration — Add 20+ References (Task e04b9319) — Add 20+ peer-reviewed refs (currently 0, 591 words)
- Expand Centrosome Dysfunction in Neurodegeneration — Add 20+ References (Task 361cd67f) — Add 20+ peer-reviewed refs (currently 0, 641 words)
Created 2026-03-23 16:29 PT
- Expand Circadian Rhythm Dysfunction in AD — Add 20+ References (Task 59d45419) — Add 20+ peer-reviewed refs (currently 0, 3817 words)
- Expand DREADDs in Neurodegeneration — Add 20+ References (Task a40d527b) — Add 20+ peer-reviewed refs (currently 0, 3750 words)
- Expand Innate Immune Signaling in AD — Add 20+ References (Task 5e43839f) — Add 20+ peer-reviewed refs (currently 0, 3681 words)
Created 2026-03-23 11:51 PT
- Expand Neuropil Threads in Neurodegeneration — Add 20+ References (Task dcbe5a35) — Add 20+ peer-reviewed refs (currently 0, 899 words)
- Expand Focal Adhesion Kinase Pathway — Add 20+ References (Task 20cf143c) — Add 20+ peer-reviewed refs (currently 0, 1252 words)
- Expand Coagulation Cascade in Neurodegeneration — Add 20+ References (Task 819feae1) — Add 20+ peer-reviewed refs (currently 0, 1290 words)
Created 2026-03-23 14:37 PT
- Expand Apoptosis Pathways in Alzheimer's Disease — Add 20+ References (Task 8cb588f1) — Add 20+ peer-reviewed refs (currently 0, 1583 words)
- Expand Neural Network Dysfunction in Alzheimer's Disease — Add 20+ References (Task 33080c4a) — Add 20+ peer-reviewed refs (currently 0, 1808 words)
- Expand Cholinergic System Degeneration in Alzheimer's Disease — Add 20+ References (Task 7fb8e104) — Add 20+ peer-reviewed refs (currently 0, 1944 words)
Created 2026-03-23 14:32 PT
- Expand Apoptosis Pathways in Alzheimer — Add 20+ References (Task 896c1519) — Add 20+ peer-reviewed refs (currently 0, 1310 words)
- Expand GWAS Findings Hub: Alzheimer — Add 20+ References (Task 363857ed) — Add 20+ peer-reviewed refs (currently 0, 1371 words)
- Expand Neural Network Dysfunction in Alzheimer — Add 20+ References (Task ae127e81) — Add 20+ peer-reviewed refs (currently 0, 1808 words)
Created 2026-03-23 13:35 PT
- Expand Metabolic Dysfunction in Alzheimer's Disease (Task 929b66e1) — Expand from 7 words (empty stub) to 2000+ words with 20+ references
- Expand Microglial Dysfunction Hypothesis in AD (Task d2641a26) — Expand from 7 words (empty stub) to 2000+ words with 20+ references
- Expand Advanced Glycation End Products in AD (Task 4db63c41) — Expand from 8 words (empty stub) to 2000+ words with 20+ references
Created 2026-03-23 05:40 PT
Per task requirements, prioritize mechanisms beyond amyloid/tau:
- Lipid Metabolism — APOE-Lipid Metabolism in Alzheimer's exists but needs expansion
- Vascular Mechanisms — Vascular Risk Factors, Cerebral Amyloid Angiopathy exist
- Immune Mechanisms — Well covered (neuroinflammation, microglia)
- Metabolic Mechanisms — Well covered (insulin resistance, NAD+)
- Infectious Hypotheses — MISSING ← Priority gap
- Epigenetic Mechanisms — Partial coverage
- RNA Metabolism — MISSING ← Priority gap
- Proteostasis — Partial coverage, need AD-specific
Each cycle should:
- Query this index for lowest-scoring mechanisms
- Select the least-covered non-amyloid/tau mechanism
- Search PubMed for recent reviews on that mechanism
- Create tasks to fill identified gaps
This index is automatically maintained by the Quest AD: Mechanisms task (Slot 3).
- AD Biomarker-to-Mechanism Mapping
- Insulin Resistance and Metabolic Dysfunction in Alzheimer's
- Tau Pathology
- Neuroinflammation in Alzheimer's Disease
- Amyloid Cascade Pathway
- Blood-Brain Barrier Breakdown in Alzheimer's
- Familial Alzheimer's Disease Genetics
- NAD+ Metabolism in Neurodegeneration
- 4R Tauopathy Molecular Mechanisms
- Tau Pathology in Alzheimer's Disease