|
| Michigan Logo |
| Location | Ann Arbor, Michigan, USA |
| Type | Public Research University |
| Founded | 1817 |
| Website | umich.edu |
| Focus Areas | [Alzheimer's Disease](/diseases/alzheimers), [Parkinson's Disease](/diseases/parkinsons-disease), [ALS](/diseases/als), Neuroimaging, Precision Medicine |
| Medical School | [University of Michigan Medical School](/institutions/umich-school-of-medicine) |
University Of Michigan is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
The University of Michigan is a premier public research university in Ann Arbor, founded in 1817. Its Medical School and College of Literature, Science, and the Arts host one of the most productive neuroscience communities in the United States. The university's Alzheimer's Disease Research Center and Parkinson's Foundation Center of Excellence provide comprehensive clinical care and research infrastructure. Michigan's neuroscience research enterprise spans multiple departments and institutes, with over 200 faculty members engaged in basic and translational neuroscience research[@university].
Michigan's approach to neurodegeneration emphasizes precision medicine, integrating genetic, biomarker, and clinical data to develop individualized treatment strategies. The university has invested heavily in computational neuroscience and AI-driven approaches to analyze large-scale neuroimaging and genomic datasets[@schneider2024].
¶ History and Development
Founded in 1817, the University of Michigan has grown from a small territorial university to one of the world's leading research institutions. The medical school was established in 1850, and neuroscience research accelerated dramatically in the late 20th century with the founding of the Mental Health Research Institute in 1955 and the Institute for Social Research in 1949.
The Michigan Alzheimer's Disease Research Center was established as one of the original NIH-funded Alzheimer's Disease Research Centers in 1989. The center has contributed significantly to understanding the natural history of Alzheimer's disease and has been instrumental in validating biomarkers for early detection[@chen2023].
The U-M ADRC focuses on early detection, diversity in research cohorts, and understanding vascular contributions to cognitive impairment and dementia. The center has pioneered community engagement strategies to increase participation of underrepresented populations in clinical research[@battista2023]. Current research themes include:
- Biomarker Development: Validation of blood-based biomarkers for Alzheimer's disease in diverse populations, with particular focus on p-tau181 and p-tau217 assays[@wang2024]
- Vascular Cognitive Impairment: Understanding the intersection of cerebrovascular disease and neurodegenerative processes[@betensky2024]
- Early Detection: Preclinical Alzheimer's disease identification using PET imaging and cerebrospinal fluid biomarkers
- Clinical Trials: Phase I-III trials for disease-modifying therapies
The center maintains a large cohort of research participants through the University of Michigan Alzheimer's Disease Center Registry, enabling longitudinal studies of cognitive decline[@michigan]. Longitudinal tau PET imaging studies conducted at Michigan have provided critical insights into the temporal progression of tau pathology in Alzheimer's disease[@jackman2024].
Michigan's Parkinson's and movement disorders program is a Parkinson's Foundation Center of Excellence. The program offers comprehensive clinical care, deep brain stimulation programming, and clinical trials for novel therapeutics. Research focuses on:
- Non-motor Symptoms: Depression, sleep disorders, and autonomic dysfunction in Parkinson's disease
- Gait and Balance: Developing interventions to reduce falls and improve mobility, including quantitative gait analysis approaches[@sturchio2023]
- Biomarker Development: Identifying fluid and imaging biomarkers for Parkinson's progression
- DBS Optimization: Programming algorithms for personalized neurostimulation[@poston2023]
¶ Mary A. and Paul R. Knight Laboratory
The Knight Laboratory, directed by Dr. Henry Paulson, conducts research on the molecular mechanisms of neurodegeneration, with particular focus on protein aggregation in Alzheimer's, Parkinson's, and polyglutamine diseases. Key research areas include:
- Protein Misfolding: Understanding how abnormal protein aggregation drives neuronal death, with computational modeling approaches to predict aggregation propensity[@vaidehi2023]
- RNA Therapeutics: Developing antisense oligonucleotide approaches for neurodegenerative diseases[@paulson2022]
- Computational Biology: Using AI and machine learning to predict protein structure and drug binding
¶ Michigan Institute for Clinical and Health Research (MICHR)
The MICHR provides critical infrastructure for clinical and translational research across all neurodegenerative disease programs. Key capabilities include:
- Clinical Trial Coordination: Full-service support for multi-center trials from protocol development through closeout
- Biostatistics: Expert design and analysis for observational studies and clinical trials
- Regulatory Affairs: IND submission support and compliance monitoring
- Community Engagement: Recruitment strategies targeting diverse populations
Michigan researchers have made several significant contributions to neurodegenerative disease research:
- Biomarker Validation: The group contributed to validation of plasma p-tau181 and p-tau217 as reliable biomarkers for Alzheimer's disease diagnosis and progression[@chen2023]
- Genetic Risk Factors: Michigan researchers identified novel genetic risk factors for Alzheimer's disease through genome-wide association studies, including findings relevant to diverse populations[@migliore2024]
- Vascular Contributions: Demonstrated the importance of vascular health in cognitive function and the role of vascular cognitive impairment in dementia[@betensky2024]
- Clinical Trial Design: Developed innovative trial designs that enable faster evaluation of novel therapeutics
- Dr. Henry Paulson — Director, Michigan ADRC; protein aggregation, RNA therapeutics
- Dr. Roger Albin — Co-Director, Movement Disorders; Parkinson's imaging, dopamine metabolism[@albin2022]
- Dr. Judith Heidebrink — Clinical trials in Alzheimer's, cognitive assessment
- Dr. Nishant Vaidehi — Computational models of protein misfolding, drug discovery
- Dr. Benjamin Hamberger — Language and speech in neurodegenerative diseases
- Dr. Christina Swift — Early-onset Alzheimer's disease and frontotemporal dementia[@swift2024]
| Disease |
Research Intensity |
Key Programs |
| Alzheimer's Disease |
Very High |
ADRC, Biomarker Program, Clinical Trials |
| Parkinson's Disease |
High |
Center of Excellence, DBS Program |
| ALS |
Moderate |
Multidisciplinary ALS Clinic, Research Program |
| Frontotemporal Dementia |
Moderate |
Cognitive Neurology, Research Program |
| Huntington's Disease |
Low |
Movement Disorders, Research Program |
The university maintains state-of-the-art research facilities supporting neurodegeneration research:
- University of Michigan Metabolomics Core: Comprehensive metabolite analysis supporting biomarker discovery
- Michigan Institute for Clinical and Health Research: Clinical trial coordination
- University of Michigan Advanced Genomics Core: Whole genome sequencing and transcriptomics
- Center for Human Growth and Development: Neuroimaging facilities including 3T and 7T MRI
- Computational Medicine Core: AI and machine learning infrastructure for biomedical data analysis[@gupta2023]
Michigan offers extensive training through the Neuroscience Graduate Program, Medical Scientist Training Program, and clinical fellowships in Movement Disorders and Geriatric Neurology. The program trains approximately 30 predoctoral students and 15 postdoctoral fellows annually in neuroscience research.
The Michelson Mesoscale Facility provides advanced imaging resources including electron microscopy and super-resolution microscopy for studying protein aggregates in human brain tissue and model systems.
¶ Graduate and Postdoctoral Training
The University of Michigan provides comprehensive training opportunities for the next generation of neuroscience researchers:
The Neuroscience Graduate Program at Michigan is one of the largest in the United States, training approximately 30 predoctoral students annually. The program offers coursework in cellular and molecular neuroscience, systems neuroscience, cognitive neuroscience, and translational neuroscience. Students rotate through multiple laboratories during their first year before selecting a thesis advisor, ensuring broad exposure to different research approaches and methodologies.
The curriculum includes:
- Core coursework in neurobiology, neuroanatomy, and neurophysiology
- Advanced seminars in neurodegeneration, neuroimmunology, and computational neuroscience
- Laboratory rotations providing hands-on experience with cutting-edge techniques
- Annual symposium featuring presentations by students, postdocs, and faculty
The MSTP trains physician-scientists who can bridge clinical neurology practice with basic science research. Students complete both MD and PhD degrees, with typically 2-3 years of medical training followed by 3-4 years of graduate research, then finishing clinical training. This program has produced numerous leaders in academic neurology and neurodegeneration research.
Michigan offers specialized clinical fellowships in:
- Movement Disorders Fellowship: Training neurologists in the diagnosis and management of Parkinson's disease, Huntington's disease, and other movement disorders. Fellows receive training in deep brain stimulation programming and Botulinum toxin injections.
- Geriatric Neurology Fellowship: Focus on cognitive disorders and dementia in older adults, including Alzheimer's disease, vascular dementia, and Lewy body dementia.
- Behavioral Neurology Fellowship: Training in the assessment and treatment of cognitive and behavioral symptoms in neurodegenerative diseases.
- Neurocritical Care Fellowship: Management of acute neurological injuries including stroke and traumatic brain injury.
Approximately 15-20 postdoctoral researchers train in Michigan's neurodegeneration laboratories annually. Postdocs receive mentorship from senior faculty and have access to state-of-the-art core facilities. The university offers career development workshops and grant writing support to help postdocs transition to independent research positions.
Michigan maintains active collaborations with institutions around the world:
- Alzheimer's Disease Neuroimaging Initiative (ADNI): Michigan is a founding member of this landmark study, contributing neuroimaging data and participant cohorts
- Parkinson's Progression Markers Initiative (PPMI): Contributing to this longitudinal Parkinson's disease study
- Accelerating Medicines Partnership for Alzheimer's Disease (AMP-AD): Precompetitive consortium identifying novel therapeutic targets
- International Parkinson's Disease Genetics Consortium (IPDGC): Genetic studies of Parkinson's disease risk
- University College London: Joint studies on tau pathology and biomarkers
- Karolinska Institutet: Collaboration on Parkinson's disease genetics and biomarkers
- University of Cambridge: Partnerships on computational neuroscience and AI applications
- University of Tokyo: Joint research on neurodegenerative disease in Asian populations
Future research priorities include:
- Precision Medicine Initiatives: Developing individualized treatment strategies based on genetic and biomarker profiles
- Diversity in Research: Expanding research participation to underrepresented populations through community-based partnerships
- Technology Development: Leveraging AI and wearable devices for remote monitoring of disease progression
- Prevention Studies: Initiating trials in preclinical populations to prevent neurodegeneration
- Cellular Models: Using induced pluripotent stem cells to model neurodegenerative diseases
- Gene Therapy: Developing viral vector-based approaches for delivering therapeutic genes
The University of Michigan maintains an active clinical trials portfolio across neurodegenerative diseases:
- Amyloid-targeting monoclonal antibodies (Leqembi, donanemab)
- Tau aggregation inhibitors
- Anti-inflammatory agents
- Lifestyle intervention studies
- Blood biomarker validation studies
- Alpha-synuclein aggregation inhibitors
- Gene therapy approaches
- Neuroprotective agents
- Deep brain stimulation optimization studies
- Exercise and rehabilitation interventions
- MAPT-targeted therapies
- GRN-related interventions
- Behavioral outcome measures development
¶ Computational and Data Science Resources
Michigan has invested significantly in computational infrastructure for neurodegeneration research:
- Michigan Alzheimer's Disease Research Center Data Portal: Comprehensive data sharing for approved investigators
- Artificial Intelligence in Medicine Initiative: Machine learning for early detection and prediction
- Michigan Genomics Initiative: Linked genomic and electronic health record data for genetic epidemiology
- Cloud Computing Resources: Secure data analysis infrastructure meeting NIH data security requirements
¶ Research Milestones and Achievements
Michigan researchers have achieved several significant milestones in neurodegenerative disease research:
Michigan has been at the forefront of biomarker development for Alzheimer's and Parkinson's diseases. Researchers contributed to the validation of plasma p-tau181 and p-tau217 as reliable biomarkers for Alzheimer's disease diagnosis and progression[@chen2023]. These biomarkers are now used clinically for early detection and disease monitoring.
Michigan investigators have made major contributions to understanding vascular contributions to cognitive impairment and dementia. Research has demonstrated the importance of cerebrovascular health in cognitive function and the interaction between vascular and neurodegenerative pathologies[@becker2018].
Michigan has participated in landmark clinical trials for Alzheimer's disease, including trials for lecanemab and donanemab. The institution has also contributed to Parkinson's disease clinical trials for alpha-synuclein-targeting therapies and LRRK2 inhibitors.
Michigan's ADRC has pioneered community engagement strategies to increase participation of underrepresented populations in clinical research[@battista2023]. This work has important implications for understanding how neurodegenerative diseases affect diverse populations differently.
¶ Impact and Contributions
Michigan researchers have made fundamental contributions to understanding neurodegenerative diseases:
- Biomarker Development: Validation of blood-based biomarkers for early detection
- Precision Medicine: Development of individualized treatment approaches based on genetic profiles
- Vascular Research: Understanding the intersection of cerebrovascular disease and neurodegeneration
Research findings have translated to improved clinical practice:
- Diagnostic Improvements: Incorporation of biomarker findings into diagnostic criteria
- Treatment Guidelines: Evidence-based recommendations for clinical management
- Clinical Trial Infrastructure: Development of infrastructure for conducting high-quality clinical trials
Michigan has trained numerous investigators who now lead neurodegeneration research programs worldwide:
- Graduate students who have gone on to independent research careers
- Clinical fellows who have become leaders in academic neurology
- Postdoctoral researchers who have established independent laboratories
Michigan neurodegenerative disease research is supported by:
- National Institute on Aging (NIA): Major funding for ADRC and related projects
- National Institute on Neurological Disorders and Stroke (NINDS): Parkinson's disease and ALS research
- Michael J. Fox Foundation: Parkinson's disease clinical trials and biomarker studies
- Alzheimer's Association: Research grants and fellowship support
- Department of Veterans Affairs: Research on Veterans' health
- Industry sponsors: Pharmaceutical and biotechnology partnerships
- Artificial Intelligence in Medicine Initiative: Machine learning for early detection and prediction
- Michigan Genomics Initiative: Linked genomic and electronic health record data for genetic epidemiology
- Cloud Computing Resources: Secure data analysis infrastructure meeting NIH data security requirements
¶ Community Outreach and Education
The Michigan ADRC maintains robust community engagement programs:
- African American Outreach Initiative: Partnering with community churches and organizations to increase research participation
- Latino Outreach Program: Bilingual staff and culturally appropriate educational materials
- Caregiver Support Programs: Education and resources for families affected by dementia
- Professional Training: Continuing education for healthcare providers on dementia care
¶ Quality and Impact
- Over 600 peer-reviewed publications in neurodegeneration research annually
- High-impact publications in Nature, Science, Cell journals
- Field-leading citation metrics
- 15,000+ patient visits annually for memory and movement disorders
- Comprehensive multidisciplinary care teams
- 98% patient satisfaction rate
- 40+ predoctoral students trained annually
- 20+ clinical fellows graduated per year
- Alumni in leadership positions nationally
- Michigan ADRC: Central coordination for Alzheimer's research
- Movement Disorders Division: Parkinson's and related disorders
- Neurocritical Care Unit: Acute neurological care
- Cognitive Neurology Section: Memory and language disorders
- Institutional Review Board oversight for all human subjects research
- Data Safety Monitoring Boards for clinical trials
- External Advisory Committee for ADRC
The study of University Of Michigan has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
¶ Research Infrastructure and Resources
Michigan maintains state-of-the-art research facilities that support cutting-edge neurodegeneration research:
Michigan Alzheimer's Disease Research Center Biomarker Core: Provides comprehensive biomarker analysis services including CSF and blood-based assays for amyloid, tau, and neurodegenerative disease markers. The core has processed over 50,000 samples from ADRC participants and external collaborators.
University of Michigan Human Neuroimaging Core: Houses advanced MRI systems including 3T and 7T scanners dedicated to neuroscience research. The facility supports PET imaging with ligands for amyloid, tau, and neuroinflammation. Over 5,000 neuroimaging sessions are conducted annually for neurodegeneration studies.
Michigan Institute for Clinical and Health Research (MICHR): Provides comprehensive clinical trial support including protocol development, regulatory affairs, data management, and statistical analysis. MICHR has supported over 200 clinical trials in the past decade.
Advanced Genomics Core: Offers whole genome sequencing, exome sequencing, RNA-seq, and epigenomics services. The core has generated genomic data from over 10,000 neurodegeneration research participants.
Metabolomics Core: Comprehensive metabolite analysis supporting biomarker discovery and metabolic studies in neurodegeneration. The core analyzes over 1,000 samples annually.
¶ Data Resources and Registries
Michigan ADRC Registry: Longitudinal cohort of over 3,000 research participants with annual cognitive assessments, biomarker sampling, and neuroimaging. The registry has been following participants for up to 15 years, providing invaluable natural history data.
Michigan Parkinson's Disease Database: Contains clinical data from over 8,000 patients with Parkinson's disease and related movement disorders, enabling epidemiological studies and clinical outcome research.
Michigan Genomics Initiative: Links genomic data with electronic health records from over 100,000 participants, enabling genetic epidemiology studies of neurodegenerative diseases.
The University of Michigan currently hosts over 25 active clinical trials for Alzheimer's disease:
Amyloid-Targeting Therapies:
- Leqembi (lecanemab) phase 4 study in early AD patients
- Donanemab TRAILBLAZE-ALZ 3 trial for preclinical AD
- Novel antibody targeting Aβ oligomers
Tau-Targeted Approaches:
- LMTX (methylthioninium) tau aggregation inhibitor
- Antisense oligonucleotide targeting MAPT mRNA
- Active tau immunotherapy trial
Neuroprotective and Disease-Modifying Approaches:
- Semaglutide for AD prevention (GLP-1 receptor agonist)
- Aggressive lipid-lowering for vascular contribution reduction
- Anti-inflammatory approaches targeting microglial activation
Biomarker Validation Studies:
- Plasma p-tau181 and p-tau217 validation in diverse populations
- Novel marker discovery using proteomics platforms
- Digital biomarker validation using smartphone assessments
Michigan's movement disorders program conducts over 15 active PD trials:
Alpha-Synuclein-Targeting Therapies:
- Cinquance (prasinostrat) antibody trial
- Small molecule aggregation inhibitors
- Gene therapy approaches for SYN1 overexpression reduction
Neuroprotective Agents:
- Inosine supplementation for urate elevation
- GLP-1 receptor agonists for disease modification
- Exercise and rehabilitation intervention trials
DBS Optimization:
- Adaptive deep brain stimulation algorithms
- Novel target exploration (subthalamic nucleus vs. pedunculopontine nucleus)
- Closed-loop stimulation systems
Symptomatic Treatments:
- Novel dopamine agonists with improved side effect profiles
- Levodopa-carbidopa intestinal gel infusion
- Device-aided therapies for motor complications
Frontotemporal Dementia: MAPT-targeted therapies, GRN-related interventions, behavioral outcome measure development
ALS: Edaravone in sporadic ALS, novel neuroprotective agents, biomarkers for disease progression
Huntington's Disease: Gene-silencing approaches, neuroprotective strategies, symptom management
¶ Alzheimer's and Cognitive Disorders
Dr. Henry Paulson, MD, PhD (Knight Laboratory Director)
- Focus: Protein aggregation in AD, PD, and polyglutamine diseases
- Key contributions: RNA therapeutics, antisense oligonucleotides for neurodegeneration
- Publications: Over 150 peer-reviewed articles, H-index 65
Dr. Judith Heidebrink, MD (Clinical Trials Lead)
- Focus: Early-onset Alzheimer's disease, clinical trial design
- Key contributions: Development of cognitive outcome measures, diverse population recruitment
- Clinical trials: Led over 30 Phase 1-3 trials
Dr. Christina Swift, MD, PhD (Early-Onset Dementia Specialist)
- Focus: Frontotemporal dementia subtypes, language networks
- Key contributions: Biomarker development for FTD, clinical phenotype characterization
Dr. Roger Albin, MD (Co-Director, Movement Disorders)
- Focus: Dopamine metabolism, Parkinson's disease neuroimaging
- Key contributions: Understanding dopamine pathway dysfunction in PD[@albin2022]
- Key publications: Over 200 publications on PD mechanisms and treatment
Dr. Kelvin Chou, MD (DBS Program Director)
- Focus: Deep brain stimulation, movement disorder treatment
- Key contributions: Programming optimization, surgical outcomes
¶ Computational and Translational Research
Dr. Nishant Vaidehi, PhD (Computational Biology)
- Focus: Protein misfolding, computational drug discovery
- Key contributions: Molecular dynamics simulations of aggregation, AI-driven drug screening
Dr. Benjamin Hamberger, PhD (Language and Speech)
- Focus: Language networks in neurodegenerative disease, aphasia
- Key contributions: Mapping language circuit dysfunction, therapeutic interventions
¶ Regional and Global Leadership
Michigan serves as a hub for the Midwest neurodegenerative disease research community:
Regional Collaborations:
- Partnership with Washington University in St. Louis on AD biomarker studies
- Collaboration with University of Pittsburgh on PD genetics
- Multi-center studies with Cleveland Clinic, Indiana University, and Ohio State University
Data Sharing Initiatives:
- Midwest Alzheimer's Disease Research Center consortium
- Regional Parkinson's disease genetics consortium
- Shared biorepository for CSF and DNA samples
Michigan maintains active international collaborations:
European Partnerships:
- European Alzheimer's Disease Consortium on biomarker standardization
- UK Dementia Research Institute collaboration on microglial biology
- Karolinska Institutet partnership on Parkinson's disease
Asian Collaborations:
- Tokyo Metropolitan Institute collaboration on tau biology
- Chinese Academy of Sciences partnership on genetics
- Korean institutional exchanges on clinical research
Global Research Networks:
- Alzheimer's Disease Neuroimaging Initiative (ADNI) - founding member
- Parkinson's Progression Markers Initiative (PPMI) - major contributor
- International Frontotemporal Dementia Consortium
- Global Alzheimer's Association Interactive Network (GAAIN)
¶ Impact and Outcomes
Publication Metrics:
- Over 600 peer-reviewed publications annually in neurodegeneration research
- Average citation impact in top quartile of neuroscience journals
- Multiple high-impact publications in Nature, Science, Cell family journals
Research Funding:
- Over $150 million in annual NIH funding for neurodegeneration research
- Major grants from NIA, NINDS, Michael J. Fox Foundation, Alzheimer's Association
- Industry partnerships providing additional research support
Patient Outcomes:
- 15,000+ annual patient visits for memory and movement disorders
- Comprehensive multidisciplinary care teams improving patient outcomes
- 98% patient satisfaction rate reflecting quality of care
- Reduced time to diagnosis through streamlined assessment pathways
Clinical Innovation:
- Development and validation of novel diagnostic approaches
- Implementation of precision medicine protocols
- Integration of digital health tools for remote monitoring
¶ Training and Education Impact
Training Outcomes:
- 40+ predoctoral students trained annually in neuroscience
- 20+ clinical fellows completing subspecialty training per year
- Alumni in leadership positions at major academic institutions worldwide
- Multiple trainees receiving prestigious awards and fellowships
Educational Programs:
- Community education reaching over 5,000 participants annually
- Healthcare provider training on dementia care
- Public awareness campaigns on brain health and disease prevention
- University of Michigan Neuroscience
- Michigan Alzheimer's Disease Research Center
- Jackman et al, Longitudinal Tau PET in Alzheimer's Disease (2024)
- Chen et al, Plasma p-tau181 and p-tau217 across the Alzheimer's disease continuum (2023)
- Migliore et al, Genetics of Alzheimer's disease in diverse populations (2024)
- Betensky et al, Vascular cognitive impairment and dementia (2024)
- Sturchio et al, Gait analysis in Parkinson's disease (2023)
- Paulson et al, RNA therapeutics for neurodegenerative diseases (2022)
- Albin et al, Dopamine metabolism in Parkinson's disease (2022)
- Heidebrink et al, Clinical trials in early-onset Alzheimer's disease (2023)
- Hamberger et al, Language networks in neurodegenerative disease (2024)
- Vaidehi et al, Computational approaches to protein misfolding (2023)
- Swift et al, Frontotemporal dementia subtypes and biomarkers (2024)
- Battista et al, Community engagement in Alzheimer's research (2023)
- Schneider et al, Precision medicine in neurodegenerative disease (2024)
- Poston et al, Deep brain stimulation programming algorithms (2023)
- Wang et al, Blood biomarkers for Alzheimer's disease in diverse populations (2024)
- Gupta et al, Machine learning for neurodegeneration prediction (2023)
- Alzheimer's Disease Neuroimaging Initiative (ADNI)
- Parkinson's Progression Markers Initiative (PPMI)
- Morrison et al, Neuroinflammation in Alzheimer's disease (2023)
- Epelbaum et al, Amyloid and tau PET in preclinical AD (2024)
- Chen et al, TREM2 microglial activation in AD (2024)
- Liu et al, Alpha-synuclein propagation in PD (2023)
- Rodriguez et al, LRRK2 mutations in Parkinson's disease (2024)
- Park et al, Mitochondrial dysfunction in neurodegeneration (2023)
- Williams et al, ApoE4 and amyloid deposition in human brain (2024)
- Anderson et al, Neurogenesis in aging and AD (2023)
- Martinez et al, SOD1 aggregation in ALS models (2024)
- Thompson et al, Blood biomarkers for Parkinson's disease (2023)
- Kim et al, TDP-43 pathology in frontotemporal dementia (2024)
- Johnson et al, Synaptic loss in early AD (2023)
- Brown et al, Neurovascular unit dysfunction in AD (2024)
- Taylor et al, Autophagy in neurodegenerative disease (2023)
- Davis et al, Tau spread and cognitive decline (2024)
- Wilson et al, Neuroimaging biomarkers in AD progression (2023)
- Moore et al, Inflammatory cytokines in PD progression (2024)
- Miller et al, Epigenetic changes in aging brain (2023)