The presence of Ab plaques constitutes a sine qua non for the expanded distribution of NFTs to merit isocortical Braak NFT stages V/VI (the pathologic substrates for most AD-type dementia)
Type: mechanistic_proposal
Confidence Level: established
Diseases Associated: Alzheimer disease
Number of Supporting Papers: 1
Source Papers:
Hypothesis: Pathologic Synergy in the Amygdala