This hypothesis proposes that Alzheimer's disease pathology originates in the hippocampus and subsequently spreads to temporal, parietal, and prefrontal association cortices via transneuronal transmission of misfolded proteins along the projection pathways of affected neurons.
Type: Mechanistic Proposal
Confidence: Supported
Related Diseases: Alzheimer's disease
Based on Braak model of neurofibrillary tau tangle progression (stages I-VI) and longitudinal MRI studies showing progression follows vulnerable fiber pathways rather than spatial proximity
hippocampus, misfolded proteins, tau, b-amyloid, transneuronal transmission, brain connectivity network, Braak model
This hypothesis is supported by multiple lines of evidence from the literature.