Yes1 — Yes Proto Oncogene 1, Src Family Tyrosine Kinase is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Symbol | YES1 |
| Full Name | YES Proto-Oncogene 1, Src Family Tyrosine Kinase |
| Chromosomal Location | 18p11.32 |
| NCBI Gene ID | 7524 |
| OMIM | 164880 |
| Ensembl ID | ENSG00000106105 |
| UniProt ID | P42681 |
| Associated Diseases | Cancer, Neurological Disorders |
YES1 (YES Proto-Oncogene 1, Src Family Tyrosine Kinase) is a member of the Src family of non-receptor tyrosine kinases (SFKs). It is widely expressed in various tissues including the brain, where it participates in signaling pathways controlling cell proliferation, differentiation, and survival. YES1 is involved in neural development and synaptic function.
YES1 encodes a member of the Src family of non-receptor tyrosine kinases (SFKs). These kinases are critical signaling molecules that regulate numerous cellular processes including cell growth, differentiation, survival, migration, and synaptic function.
Src family kinases consist of an N-terminal myristoylation site for membrane association, a unique domain, SH3 and SH2 domains for protein-protein interactions, and a catalytic tyrosine kinase domain. They are activated by various receptors including growth factor receptors, integrins, and immune receptors.
In the nervous system, YES1 plays important roles in synaptic plasticity, NMDA receptor signaling, and neuronal survival. It is involved in the phosphorylation of various substrates including NMDA receptor subunits, PSD-95, and tau.
YES1 is expressed in most tissues including brain. Expression is regulated during development and by neuronal activity.
Src family kinase inhibitors are being investigated:
The study of Yes1 — Yes Proto Oncogene 1, Src Family Tyrosine Kinase has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.