Gene SymbolXCL1
Full NameX-C Motif Chemokine Ligand 1 (Lymphotactin)
Chromosomal Location1q24.2
Ensembl IDENSG00000143184
Associated DiseasesImmune Disorders, Viral Infections
The XCL1 gene encodes lymphotactin, a C-class chemokine that signals through the XCR1 receptor. Unlike most chemokines, lymphotactin has only one disulfide bond, giving it a unique structure among chemokine families [1].
XCL1 is primarily produced by activated CD8+ T cells and natural killer (NK) cells, and plays important roles in immune surveillance and cross-presentation [2].
XCL1 functions as:
- Lymphocyte Chemotaxis: Attracts XCR1-expressing cells
- Immune Surveillance: Recruits dendritic cells and T cells
- Cross-Presentation: Facilitates antigen cross-presentation to CD8+ T cells
- Viral Immunity: Important for antiviral immune responses
- Viral Infections: Elevated in various viral infections
- Cancer: Associated with anti-tumor immunity
- Autoimmune Diseases: Altered in some autoimmune conditions
- Activated CD8+ T cells: Primary source
- Natural Killer cells: High expression
- Dendritic cells: Induced upon activation
- NCBI Gene: XCL1
- UniProt: XCL1