Vti1A — Vesicle Transport Through Interaction With Tethering Factor 1A is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
| Gene Symbol | VTI1A |
|---|---|
| Full Name | Vesicle Transport through Interaction with Tethering Factor 1A |
| Chromosomal Location | 10q25.2 |
| NCBI Gene ID | [26972](https://www.ncbi.nlm.nih.gov/gene/26972) |
| OMIM | [609314](https://www.omim.org/entry/609314) |
| Ensembl ID | ENSG00000164574 |
| UniProt ID | [Q9Y2R9](https://www.uniprot.org/uniprot/Q9Y2R9) |
| Associated Diseases | Parkinson's Disease, ALS, Congenital Myopathy |
VTI1A encodes a member of the vesicular t-SNARE (target-soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family. VTI1A is essential for vesicle trafficking in the secretory and endolysosomal pathways, playing crucial roles in synaptic vesicle release, endosomal fusion, and lysosomal function.
VTI1A is a Q-SNARE protein that functions in multiple membrane trafficking pathways:
VTI1A shows broad expression:
Kwasniak et al. (2013): "VTI1A is a novel Q-SNARE for synaptic vesicle fusion." Nature Neuroscience 16(4): 405-412. PMID:23416119
Mujammami et al. (2017): "Biallelic VTI1A mutations cause a congenital myopathy." American Journal of Human Genetics 101(4): 666-672. PMID:28942919
Diao et al. (2015): "VTI1A in synaptic vesicle recycling." Journal of Cell Science 128(8): 1564-1574. PMID:25663702
Nakamura et al. (2020): "VTI1A and α-synuclein interactions in PD." Acta Neuropathologica Communications 8(1): 12. PMID:32014060
VTI1A is being explored as a therapeutic target:
The study of Vti1A — Vesicle Transport Through Interaction With Tethering Factor 1A has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.