Vti1A Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
VTI1A (Vesicular Transport Interactor 1A) is a soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE) protein involved in intracellular membrane trafficking. Originally identified as a component of the vesicle transport machinery, VTI1A has emerged as an important protein in synaptic function and has been implicated in neurodegenerative diseases through its role in autophagy, lysosomal trafficking, and protein homeostasis. This page covers the VTI1A gene structure, protein function, and its involvement in Alzheimer's Disease, Parkinson's Disease, and other neurodegenerative conditions. [1]
| Property | Value | [2]
|----------|-------| [3]
| Gene Symbol | VTI1A | [4]
| Gene Name | Vesicle Transport Interactor 1A |
| Chromosomal Location | 10q25.1 |
| NCBI Gene ID | 143187 |
| UniProt ID | Q9MPM7 |
| Protein Family | SNARE family (Qc-SNARE) |
| Molecular Weight | ~22 kDa |
The VTI1A gene consists of 8 exons spanning approximately 10 kb of genomic DNA. The gene encodes a protein with 193 amino acids containing an N-terminal Habc domain and a C-terminal transmembrane region typical of Qc-SNAREs.
VTI1A functions as a Qc-SNARE (glutamine-containing SNARE) in intracellular trafficking:
VTI1A forms SNARE complexes with:
The resulting four-helix bundle drives membrane fusion.
VTI1A contributes to AD through:
Key Evidence:
| Approach | Mechanism | Status |
|---|---|---|
| SNARE Modulation | Enhance assembly/disassembly | Research |
| Autophagy Enhancement | Upstream of VTI1A | Preclinical |
| Gene Therapy | Increase expression | Experimental |
The study of Vti1A Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.