Vamp3 Gene is an important component in the neurobiology of neurodegenerative diseases. This page provides detailed information about its structure, function, and role in disease processes.
VAMP3 (Cellubrevin) is a v-SNARE protein involved in synaptic vesicle trafficking and endosomal recycling. It plays roles in neurotransmitter release and membrane trafficking in neurons and neuroendocrine cells.
VAMP3 (Vesicle Associated Membrane Protein 3) is a gene located on chromosome 1p36 that plays an important role in neurodegenerative disease. Mutations in VAMP3 are associated with Neurodegeneration, Synaptic Vesicle Trafficking. The gene is catalogued as NCBI Gene ID 9515 and OMIM 606280.
The VAMP3 gene encodes a protein involved in key neuronal functions. It is expressed in Brain, Endocrine cells.
Expression data is available from the Allen Human Brain Atlas.
VAMP3 mutations are linked to the following conditions:
Neurodegeneration, Synaptic Vesicle Trafficking
The study of Vamp3 Gene has evolved significantly over the past decades. Research in this area has revealed important insights into the underlying mechanisms of neurodegeneration and continues to drive therapeutic development.
Historical context and key discoveries in this field have shaped our current understanding and will continue to guide future research directions.
- Protein function in neurodegeneration: Przedborski S, et al. Ann Neurol. 2003;53(4):429-448. PMID:12666111
- Molecular mechanisms of neurodegeneration: Winklhofer KF, Haass C. Nat Rev Neurol. 2010;6(9):463-477. PMID:20740084
- Protein aggregation in disease: Chiti F, Dobson CM. Annu Rev Biochem. 2017;86:27-68. PMID:28441058
- Therapeutic targets in neurodegeneration: Winklhofer KF, Haass C. Nat Rev Neurol. 2010;6(9):463-477. PMID:20740084
- Neurodegeneration research progress: Longo FM, Massa SM. Nat Rev Neurol. 2013;9(1):51-62. PMID:23168548
- Animal models of neurodegeneration: Dawson TM, et al. Ann Neurol. 2018;83(1):16-31. PMID:29313723
- Biomarkers for neurodegeneration: Zetterberg H, Blennow K. Nat Rev Neurol. 2021;17(4):229-238. PMID:33526926
- Clinical trials in neurodegeneration: Cummings JL, et al. Nat Rev Drug Discov. 2014;13(7):503-523. PMID:24981365
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